Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation-predominant irritable bowel syndrome.
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DOI: 10.1016/j.lfs.2020.117960
Abstract: BACKGROUND Intestinal GC-C/cGMP pathway may be involved in visceral hypersensitivity and fluid secretion in irritable bowel syndrome (IBS). The guanylcyclase C agonist linaclotide, approved for IBS- constipation, is contraindicated in children as it may cause… read more here.
Keywords: ibs; irritable bowel; tadalafil; tadalafil linaclotide ... See more keywords