TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways
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DOI: 10.1007/s12072-019-09997-6
Abstract: Background This study aimed to investigate the roles and mechanisms of tenofovir alafenamide fumarate (TAF)/tenofovir disoproxil fumarate (TDF) in treating liver fibrosis. Methods The effects of TAF/TDF on carbon tetrachloride (CCl 4 )-induced liver fibrosis… read more here.
Keywords: signaling pathways; liver fibrosis; inflammasome signaling; nlrp3 inflammasome ... See more keywords
IDDF2018-ABS-0105 No resistance to TENOFOVIR ALAFENAMIDE detected through 96 weeks of treatment in patients with chronic hepatitis B
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DOI: 10.1136/gutjnl-2018-iddfabstracts.207
Abstract: Background Presented herein are the post Week 48 through Week 96 resistance analyses for 2 Phase 3 studies evaluating tenofovir alafenamide (TAF) versus tenofovir disoproxil fumarate(TDF) for the treatment of chronic hepatitis B (CHB) in… read more here.
Keywords: week; treatment; site substitutions; weeks treatment ... See more keywords