Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
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DOI: 10.1021/acs.jmedchem.1c01999
Abstract: Bromodomains regulate chromatin remodeling and gene transcription through recognition of acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a subunit of general transcription factor TFIID, initiates preinitiation complex formation and cellular transcription. TAF1… read more here.
Keywords: taf1; transcription; taf1 tandem; discovery dual ... See more keywords