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   Articles with "tafenoquine" as a keyword



Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers

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recommendations! Published in 2019 at "Drug Safety"

DOI: 10.1007/s40264-019-00839-w

Abstract: IntroductionTafenoquine has been recently registered for the prevention of relapse in Plasmodium vivax malaria.ObjectiveThis study assessed the pharmacodynamic effects of 300-mg single-dose tafenoquine on the retina.MethodsThis phase I, prospective, multicenter, randomized, single-masked, placebo-controlled, parallel-group study… read more here.

Keywords: placebo; ophthalmic safety; dose tafenoquine; tafenoquine ... See more keywords

Tafenoquine: First Global Approval

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recommendations! Published in 2018 at "Drugs"

DOI: 10.1007/s40265-018-0979-2

Abstract: Tafenoquine (Krintafel™, Arakoda™), an orally-active 8-aminoquinoline anti-malarial drug, is a long-acting analogue of primaquine with activity against pre-erythrocytic (liver) and erythrocytic (asexual) forms as well as gametocytes of Plasmodium species that include Plasmodium vivax (P.… read more here.

Keywords: vivax malaria; global approval; vivax; tafenoquine ... See more keywords

Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adk4492

Abstract: Approximately 3.3 billion people live with the threat of Plasmodium vivax malaria. Infection can result in liver-localized hypnozoites, which when reactivated cause relapsing malaria. This work demonstrates that an enzyme-cleavable polymeric prodrug of tafenoquine addresses… read more here.

Keywords: therapeutic window; liver targeted; targeted polymeric; tafenoquine ... See more keywords

Clinical utility of tafenoquine in the prevention of relapse of Plasmodium vivax malaria: a review on the mode of action and emerging trial data

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recommendations! Published in 2019 at "Infection and Drug Resistance"

DOI: 10.2147/idr.s151031

Abstract: Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of Plasmodium vivax, including dormant liver stages – so called hypnozoites. Its long half-life of ~15 days is allowing for a single exposure… read more here.

Keywords: vivax malaria; drug; plasmodium vivax; mode action ... See more keywords