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Published in 2019 at "Drug Safety"
DOI: 10.1007/s40264-019-00839-w
Abstract: IntroductionTafenoquine has been recently registered for the prevention of relapse in Plasmodium vivax malaria.ObjectiveThis study assessed the pharmacodynamic effects of 300-mg single-dose tafenoquine on the retina.MethodsThis phase I, prospective, multicenter, randomized, single-masked, placebo-controlled, parallel-group study…
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Keywords:
placebo;
ophthalmic safety;
dose tafenoquine;
tafenoquine ... See more keywords
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Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0979-2
Abstract: Tafenoquine (Krintafel™, Arakoda™), an orally-active 8-aminoquinoline anti-malarial drug, is a long-acting analogue of primaquine with activity against pre-erythrocytic (liver) and erythrocytic (asexual) forms as well as gametocytes of Plasmodium species that include Plasmodium vivax (P.…
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Keywords:
vivax malaria;
global approval;
vivax;
tafenoquine ... See more keywords
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Published in 2019 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s151031
Abstract: Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of Plasmodium vivax, including dormant liver stages – so called hypnozoites. Its long half-life of ~15 days is allowing for a single exposure…
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Keywords:
vivax malaria;
drug;
plasmodium vivax;
mode action ... See more keywords