Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers
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DOI: 10.1007/s40264-019-00839-w
Abstract: IntroductionTafenoquine has been recently registered for the prevention of relapse in Plasmodium vivax malaria.ObjectiveThis study assessed the pharmacodynamic effects of 300-mg single-dose tafenoquine on the retina.MethodsThis phase I, prospective, multicenter, randomized, single-masked, placebo-controlled, parallel-group study… read more here.
Keywords: placebo; ophthalmic safety; dose tafenoquine; tafenoquine ... See more keywords
Tafenoquine: First Global Approval
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DOI: 10.1007/s40265-018-0979-2
Abstract: Tafenoquine (Krintafel™, Arakoda™), an orally-active 8-aminoquinoline anti-malarial drug, is a long-acting analogue of primaquine with activity against pre-erythrocytic (liver) and erythrocytic (asexual) forms as well as gametocytes of Plasmodium species that include Plasmodium vivax (P.… read more here.
Keywords: vivax malaria; global approval; vivax; tafenoquine ... See more keywords
Clinical utility of tafenoquine in the prevention of relapse of Plasmodium vivax malaria: a review on the mode of action and emerging trial data
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DOI: 10.2147/idr.s151031
Abstract: Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of Plasmodium vivax, including dormant liver stages – so called hypnozoites. Its long half-life of ~15 days is allowing for a single exposure… read more here.
Keywords: vivax malaria; drug; plasmodium vivax; mode action ... See more keywords