Optimization of Higher-Energy Collisional Dissociation Fragmentation Energy for Intact Protein-Level Tandem Mass Tag Labeling.
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DOI: 10.1021/acs.jproteome.2c00549
Abstract: Isobaric chemical tag labeling (e.g., TMT) is a commonly used approach in quantitative proteomics, and quantification is enabled through detection of low-mass reporter ions generated after MS2 fragmentation. Recently, we have introduced and optimized an… read more here.
Keywords: intact protein; fragmentation; energy; tag labeling ... See more keywords