T‐cell activation RhoGTPase‐activating protein plays an important role in TH17‐cell differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.27
Abstract: T‐cell activation RhoGTPase‐activating protein (TAGAP) is a GTPase‐activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome‐wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the… read more here.
Keywords: th17; tagap; activating protein; differentiation ... See more keywords
Identification and in silico analysis of functional SNPs of human TAGAP protein: A comprehensive study
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188143
Abstract: Genetic polymorphisms in TAGAP gene have been associated with many diseases including rheumatoid arthritis, multiple sclerosis and other autoimmune disorders. Identifying functional SNPs in such disease associated genes is an uphill task hence before planning… read more here.
Keywords: tagap protein; tagap; study; functional snps ... See more keywords
T-cell activation Rho GTPase-activating protein maintains intestinal homeostasis by regulating intestinal T helper cells differentiation through the gut microbiota
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1030947
Abstract: Common variants of the T-cell activation Rho GTPase-activating protein (TAGAP) are associated with the susceptibility to human inflammatory bowel diseases (IBDs); however, the underlying mechanisms are still unknown. Here, we show that TAGAP deficiency or… read more here.
Keywords: rho gtpase; gut; cell activation; activation rho ... See more keywords