Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.015
Abstract: The rapid emergence of antibiotic-resistant infections is prompting increased interest in phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue in the successful development of phage therapies. Through natural evolution and structural… read more here.
Keywords: tail fiber; range; phage; resistance ... See more keywords
Development of a Bacteriophage Tail Fiber-Based Latex Agglutination Assay for Rapid Clinical Screening of Burkholderia pseudomallei.
Sign Up to like & getrecommendations! Published in 2021 at "Applied and environmental microbiology"
DOI: 10.1128/aem.03019-20
Abstract: Melioidosis is a life-threatening disease in humans caused by the Gram- negative bacterium Burkholderia pseudomallei As severe septicemic melioidosis can lead to death within 24 to 48 hours, a rapid diagnosis of melioidosis is critical… read more here.
Keywords: pseudomallei; tail fiber; burkholderia; agglutination ... See more keywords
R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.
Sign Up to like & getrecommendations! Published in 2019 at "PLOS ONE"
DOI: 10.2210/pdb6cxb/pdb
Abstract: R pyocins are ɸCTX-like myophage tailocins of Pseudomonas sp. Adsorption of R pyocins to target strains occurs by the interaction of tail fiber proteins with core lipopolysaccharide (LPS). Here, we demonstrate that N-terminally truncated R… read more here.
Keywords: tail; pyocin tail; tail fiber; binding domain ... See more keywords
Evaluating Phage Tail Fiber Receptor-Binding Proteins Using a Luminescent Flow-Through 96-Well Plate Assay
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.741304
Abstract: Phages have demonstrated significant potential as therapeutics in bacterial disease control and as diagnostics due to their targeted bacterial host range. Host range has typically been defined by plaque assays; an important technique for therapeutic… read more here.
Keywords: phage tail; tail fiber; phage; receptor ... See more keywords