ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202405417
Abstract: Emerging studies have demonstrated that M1 macrophage polarization and oxidative stress play important roles in calcium oxalate (CaOx) induced kidney injury, which leads to increased crystals deposition. ROS scavenging nanozymes and kidney-targeted nanoparticles for antioxidant… read more here.
Keywords: induced kidney; tak 242; injury; kidney injury ... See more keywords
Protective effect of Toll-like receptor 4 antagonist on inflammation, EEG, and memory changes following febrile seizure in Wistar rats
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113723
Abstract: Neuroinflammation and fever are the main triggers in febrile seizures (FS). Focusing on inflammatory pathways and anti-inflammatory drugs could compensate for the limitations of existing medications. The aim of this study is to evaluate the… read more here.
Keywords: tak 242; memory; toll like; effect ... See more keywords
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108595
Abstract: This study aimed to explore the effects of N-acetylserotonin (NAS) on the expression of interleukin-1β (IL-1β) in the retina of retinal ischemia-reperfusion injury (RIRI) rats via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/nod-like receptor… read more here.
Keywords: tak 242; riri; riri nas; group ... See more keywords
TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.05.021
Abstract: The present study aims to investigate the effects of toll-like receptor 4 (TLR4) antagonist in an ovalbumin (OVA)-induced mouse model of combined allergic rhinitis and asthma syndrome (CARAS). An OVA-induced mouse model of CARAS was… read more here.
Keywords: allergic rhinitis; tak 242; combined allergic; infiltration ... See more keywords
Toll-like receptor 4 signaling pathway is correlated with pathophysiological characteristics of AML patients and its inhibition using TAK-242 suppresses AML cell proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107202
Abstract: PURPOSE Acute myeloid leukemia (AML) is one of the most severe blood cancers. Many studies have revealed that inflammation has an essential role in the progression of hematopoietic malignancies. Since the toll-like receptor 4 (TLR4)… read more here.
Keywords: characteristics aml; tak 242; aml patients; pathophysiological characteristics ... See more keywords
TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-κB Signaling Pathways in Rats
Sign Up to like & getrecommendations! Published in 2020 at "Prehospital and Disaster Medicine"
DOI: 10.1017/s1049023x20001132
Abstract: Abstract Background: To investigate if toll-like receptor (TLR) 4/nuclear factor-kappa B (NF-κB) signaling pathways mediated crush injury induced acute kidney injury (AKI) in rats, and if TAK-242 (a specific inhibitor of TLR4) attenuates the injury… read more here.
Keywords: crush injury; tak 242; signaling pathways; injury ... See more keywords
Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00492
Abstract: We previously demonstrated that the potent TLR4 inhibitor TAK-242 could be covalently conjugated to pancreatic islets using a linker that afforded an effective sustained delivery of the active drug after transplant. This drug-eluting tissue achieved… read more here.
Keywords: two stage; release mechanism; stage release; tlr4 ... See more keywords
TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Renal Failure"
DOI: 10.1080/0886022x.2024.2313176
Abstract: Abstract Objective This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and treatment… read more here.
Keywords: tlr4 signaling; clp; tak 242; kidney injury ... See more keywords
Treatment strategies and mechanisms associated with the prevention of NASH-associated HCC by a toll-like receptor 4 inhibitor.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-22-0332
Abstract: We evaluated the cancer preventive efficacy of TAK-242, an inhibitor of toll-like receptor 4 (TLR4), in a mouse model of hepatocellular carcinoma (HCC) occurring in the context of non-alcoholic steatohepatitis (NASH). We also assessed the… read more here.
Keywords: tak 242; toll like; prevention; like receptor ... See more keywords
The Toll-like receptor 4 antagonist TAK-242 in combination with sodium hyaluronate alleviates postoperative abdominal adhesion in a mouse model
Sign Up to like & getrecommendations! Published in 2024 at "BMC Medical Genomics"
DOI: 10.1186/s12920-024-02031-1
Abstract: Postoperative abdominal adhesion is one of the most common complications after abdominal surgery. The Toll-like receptor 4 (TLR4) signaling pathway is one of the most common inflammation-related pathways, and it has been demonstrated that TLR4… read more here.
Keywords: toll like; adhesion; abdominal adhesion; tak 242 ... See more keywords
TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Microbial Cell Factories"
DOI: 10.1186/s12934-020-01417-x
Abstract: Background The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis. Results At the phylum… read more here.
Keywords: colitis; jak2 stat3; tak 242; gut microbiota ... See more keywords