Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav3660
Abstract: A next generation cancer drug candidate, a CDC7 inhibitor, TAK-931, was developed, which is being evaluated in clinical trials. Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are widely used as treatments… read more here.
Keywords: potential target; selective inhibitor; inhibitor; tak 931 ... See more keywords
Abstract A093: Potential combination partners for a novel CDC7-selective Inhibitor, TAK-931
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a093
Abstract: Background: Cell division cycle 7 (CDC7) is a serine/threonine kinase, which plays important roles in initiation of DNA replication. We developed a CDC7-selective inhibitor, TAK-931, designed to inhibit CDC7 activity in a time-dependent and ATP-competitive… read more here.
Keywords: potential combination; selective inhibitor; tak 931; combination ... See more keywords
Abstract 3073: Potential predictive biomarkers of clinical responses for a novel CDC7-selective inhibitor TAK-931
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DOI: 10.1158/1538-7445.am2017-3073
Abstract: Cell division cycle 7 (CDC7) is a serine/threonine kinase, which plays important roles in initiation of DNA replication by phosphorylating MCM2. Kinase activity of CDC7 is controlled by its binding protein DBF4 in a cell-cycle… read more here.
Keywords: cdc7; inhibitor tak; tak 931; cancer ... See more keywords
Abstract 5041: Translational pharmacokinetic-pharmacodynamic xenograft model for TAK-931, a small molecule cell division cycle 7 (CDC7) kinase inhibitor
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5041
Abstract: TAK-931 is a small molecule inhibitor of the cell division cycle 7 (CDC7) kinase. As a serine/threonine kinase that contributes to DNA replication and the DNA damage response, CDC7 is hypothesized to be a promising… read more here.
Keywords: cdc7; inhibitor; 931 small; kinase ... See more keywords