Paclitaxel induces apoptosis through the TAK1–JNK activation pathway
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12917
Abstract: Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancers and leukemia. PTX‐induced apoptosis is associated with p38 mitogen‐activated protein kinase (p38 MAPK), extracellular signal‐regulated… read more here.
Keywords: apoptosis; jnk; cleavage; tak1 ... See more keywords
Emerging role of TAK1 in the regulation of skeletal muscle mass
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202300003
Abstract: Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF‐β‐activated kinase 1 (TAK1)… read more here.
Keywords: regulation skeletal; muscle; tak1; skeletal muscle ... See more keywords
Hepatic Regulator of G protein Signaling 5 Ameliorates NAFLD by Suppressing TAK1-JNK/p38 Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31242
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, that has no specific pharmacological treatments partially due to the unclear pathophysiological mechanisms. Regulators of G protein signaling (RGS) proteins… read more here.
Keywords: protein; jnk p38; protein signaling; tak1 ... See more keywords
Switch-associated protein 70 protects against nonalcoholic fatty liver disease via suppression of TAK1.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32213
Abstract: BACKGROUND AND AIMS Nonalcoholic fatty liver disease (NAFLD) is a progressive disease without known effective drug treatments. Switch-associated protein 70 (SWAP70) is a guanine nucleotide exchange factor that participates in the regulation of many cellular… read more here.
Keywords: fatty liver; tak1; disease; swap70 ... See more keywords
The contribution of toll‐like receptor signaling to the development of liver fibrosis and cancer in hepatocyte‐specific TAK1‐deleted mice
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DOI: 10.1002/ijc.31029
Abstract: Hepatocyte death is associated with liver inflammation, fibrosis and hepatocellular carcinoma (HCC). Damaged cells trigger inflammation through activation of Toll‐like receptors (TLRs). Although the role of TLR4 in HCC development has been reported, the role… read more here.
Keywords: tak1; fibrosis; hep mice; tak1 hep ... See more keywords
Salidroside ameliorates pathological cardiac hypertrophy via TLR4‐TAK1‐dependent signaling
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DOI: 10.1002/ptr.7701
Abstract: Salidroside, a prominent active ingredient in traditional Chinese medicines, is garnering increased attention because of its unique pharmacological effects against ischemic heart disease via MAPK signaling, which plays a critical role in regulating the evolution… read more here.
Keywords: hypertrophy; jnk p38; tak1; tlr4 ... See more keywords
Regulation of Tak1 alternative splicing by splice-switching oligonucleotides.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.160
Abstract: Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result… read more here.
Keywords: tak1; switching oligonucleotides; splice switching; alternative splicing ... See more keywords
Alisma canaliculatum ethanol extract suppresses inflammatory responses in LPS-stimulated macrophages, HCl/EtOH-induced gastritis, and DSS-triggered colitis by targeting Src/Syk and TAK1 activities.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.03.022
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Alisma canaliculatum A.Braun & C.D.Bouché, distributed in Korea, Japan, China, and Taiwan, is a traditional medicine. In particular, the stem and root of Alisma canaliculatum A.Braun & C.D.Bouché are prescribed to relieve various… read more here.
Keywords: src syk; tak1; colitis; canaliculatum ... See more keywords
Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105257
Abstract: TGFβ-activated kinase 1 (TAK1) is a master regulator that drives multiple cell death and proinflammatory signaling pathways, making it a promising therapeutic target to treat ischemic stroke. However, whether targeting TAK1 could improve stroke outcomes… read more here.
Keywords: tak1; ovariectomized female; microglial macrophage; female mice ... See more keywords
Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance.
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DOI: 10.1016/j.phrs.2021.105482
Abstract: BACKGROUND AND PURPOSE The aim of this work was to investigate the role and signal transduction of toll-like receptor 4 (TLR4), TGF-β-activated kinase 1 (TAK1) and nod-like receptor protein 3 (NLRP3) in microglial in the… read more here.
Keywords: morphine induced; morphine; tolerance; tak1 ... See more keywords
The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.114705
Abstract: Occupational exposure to trichloroethylene (TCE) has been associated with severe, generalized contact hypersensitivity (CHS) skin disorder, which is considered a delayed-type hypersensitivity reaction mediated by antigen-specific T cells. Transforming growth factor-β activated kinase-1 (TAK1) is… read more here.
Keywords: trichloroethylene; cd4 cell; tce; tak1 ... See more keywords