Integrated multi-omics study identifies ursolic acid as a novel therapeutic agent targeting the TNF-α/TAK1/IKKβ/NF-κB axis in hepatic sinusoidal obstruction syndrome
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DOI: 10.1182/blood-2025-4091
Abstract: Hepatic sinusoidal obstruction syndrome (SOS) is a lethal complication of hematopoietic stem cell transplantation (HSCT) with limited targeted therapies. The busulfan-cyclophosphamide (BUCY) conditioning regimen induces endothelial injury, thereby initiating a thromboinflammatory cascade. While TNF-α/NF-κB signaling… read more here.
Keywords: bucy; tak1 ikk; tnf; p65 ... See more keywords