Generation of TALE-Based Designer Epigenome Modifiers.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7774-1_4
Abstract: Manipulation of gene expression can be facilitated by editing the genome or the epigenome. Precise genome editing is traditionally achieved by using designer nucleases which are generally exploited to eliminate a specific gene product. Upon… read more here.
Keywords: designer; tale based; designer epigenome; based designer ... See more keywords
Assembly of TALE-based DNA scaffold for the enhancement of exogenous multi-enzymatic pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.03.008
Abstract: Synthetic scaffold systems, which exhibit enzyme clustering effect, have been considered as an important parallel approach for metabolic flux control and pathway enhancement. Here, we described an improved DNA-based scaffold system for synthetic tri-enzymatic pathway… read more here.
Keywords: tale based; based dna; assembly tale; pathway ... See more keywords
A multiplexable TALE-based binary expression system for in vivo cellular interaction studies
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01592-3
Abstract: Binary expression systems have revolutionised genetic research by enabling delivery of loss-of-function and gain-of-function transgenes with precise spatial-temporal resolution in vivo. However, at present, each existing platform relies on a defined exogenous transcription activator capable… read more here.
Keywords: tale based; system; expression; function ... See more keywords