Context and number of noncanonical repeat variable diresidues impede the design of TALE proteins with improved DNA targeting
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DOI: 10.1002/pro.3801
Abstract: Transcription activator‐like effector (TALE) proteins have been used extensively for targeted binding of fusion proteins to loci of interest in (epi)genome engineering. Such approaches typically utilize four canonical TALE repeat variable diresidue (RVD) types, corresponding… read more here.
Keywords: tale proteins; tale; repeat variable; improved specificity ... See more keywords