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   Articles with "talin" as a keyword



Talin is required to increase stiffness of focal molecular complex in its early formation process.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.08.091

Abstract: For cellular adaptation in mechanical environments, it is important to consider transmission of forces from the outside to the inside of cells via a focal molecular complex. The focal molecular complex, which consists of integrin,… read more here.

Keywords: nascent complex; talin; molecular complex; focal molecular ... See more keywords

Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity

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recommendations! Published in 2017 at "Journal of Neuroimmunology"

DOI: 10.1016/j.jneuroim.2017.02.008

Abstract: Previously, we identified anti-Talin-1 antibodies in the serum of MS. In this case, we measured the serum soluble Talin-1 (sTalin-1) levels by enzyme-linked immunosorbent assay. The serum sTalin-1 levels were significantly higher in 40 patients… read more here.

Keywords: serum soluble; disease; serum; stalin levels ... See more keywords

Tension Enhances the Binding Affinity of β1 Integrin by Clamping Talin Tightly: An Insight from Steered Molecular Dynamics Simulations

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recommendations! Published in 2022 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.2c00963

Abstract: Integrin activation is a predominant step for cell-cell and cell-ECM interactions. Talin and Kindlin are mechanosensitive adaptor proteins that bind to the integrin cytoplasmic tail and mediate integrin activation, cytoskeleton rearrangement, and focal adhesion assembly.… read more here.

Keywords: cell; integrin; tension; talin ... See more keywords

The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2109329119

Abstract: Significance Talin is a mechanosensitive adaptor protein that links integrins to the actin cytoskeleton at cell–extracellular matrix adhesions. Although the C-terminal actin-binding domain ABS3 of talin is required for function, it binds weakly to actin… read more here.

Keywords: actin; terminal actin; binding domain; actin binding ... See more keywords

Talin autoinhibition is required for normal hemostasis.

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recommendations! Published in 2025 at "Platelets"

DOI: 10.1080/09537104.2025.2555197

Abstract: ABSTRACT The integrin family of extracellular matrix (ECM) adhesion receptors plays a central role in platelet function, including adhesion and aggregation. In resting platelets, integrins exist in a low-affinity state for their ligands, and are… read more here.

Keywords: talin; talin autoinhibition; role; autoinhibition ... See more keywords

Clinical significance of Talin-1 and HER-2 status in different types of gastric carcinoma

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recommendations! Published in 2024 at "Biomarkers"

DOI: 10.1080/1354750x.2024.2423270

Abstract: Abstract Background Talin-1 (TLN1) is crucial in cell migration, metastasis, and cancer development. This study evaluated Talin-1 expression and its clinical significance in gastric cancer (GC), along with human epidermal growth factor receptor-2 (HER-2) expression… read more here.

Keywords: cancer; talin; talin expression; clinical significance ... See more keywords

AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway

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recommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.122.318647

Abstract: Background: AGK (acylglycerol kinase) was first identified as a mitochondrial transmembrane protein that exhibits a lipid kinase function. Recent studies have established that AGK promotes cancer growth and metastasis, enhances glycolytic metabolism and function fitness… read more here.

Keywords: iib mediated; mediated bidirectional; agk; talin ... See more keywords

Talin in mechanotransduction and mechanomemory at a glance.

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recommendations! Published in 2021 at "Journal of cell science"

DOI: 10.1242/jcs.258749

Abstract: Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which… read more here.

Keywords: mechanotransduction mechanomemory; glance; mechanomemory glance; talin mechanotransduction ... See more keywords

Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3

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recommendations! Published in 2025 at "Journal of Cell Science"

DOI: 10.1242/jcs.263595

Abstract: ABSTRACT Talin regulates the adhesion and migration of cells in part by promoting the affinity of integrins for extracellular matrix proteins, a process that in cells such as endothelial cells and platelets requires the direct… read more here.

Keywords: rap1; gtp; talin; activation ... See more keywords

Actin-binding domains mediate the distinct distribution of two Dictyostelium Talins through different affinities to specific subsets of actin filaments during directed cell migration

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recommendations! Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0214736

Abstract: Although the distinct distribution of certain molecules along the anterior or posterior edge is essential for directed cell migration, the mechanisms to maintain asymmetric protein localization have not yet been fully elucidated. Here, we studied… read more here.

Keywords: actin binding; cell migration; actin filaments; talin ... See more keywords

The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.836797

Abstract: Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs; however, the relative contribution of… read more here.

Keywords: domain; migration; talin; cell migration ... See more keywords