Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation.
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DOI: 10.1182/blood.2020005348
Abstract: Rap1 is a major convergence point of the platelet signaling pathways that result in talin1 binding to the integrin b cytoplasmic domain and consequent integrin activation, platelet aggregation, and effective hemostasis. The nature of the… read more here.
Keywords: talin1 principal; platelet; rap1; integrin activation ... See more keywords