Flexible Etherified and Esterified Triphenylethylene Derivatives and Their Evaluation on ER‐positive and Triple‐Negative Breast Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100720
Abstract: Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) with potential clinical benefits for all stages of breast cancer. TAM is primarily metabolized to more potent metabolites via polymorphic CYP2D6. This affects the clinical outcome… read more here.
Keywords: tam; flexible etherified; breast cancer; cell lines ... See more keywords
Hepatic effects of long‐term tamoxifen administration to cycling female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22293
Abstract: The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long‐term TAM administration to cycling… read more here.
Keywords: term; long term; administration cycling; tam ... See more keywords
POR overexpression induces tamoxifen‐resistance in breast cancer through the STAT1/c‐Myc pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23481
Abstract: Breast cancer is the most common cancer in women worldwide. Although tamoxifen (TAM), a selective estrogen receptor (ER) modulator, is widely used to treat ER‐positive breast cancers, resistance to TAM remains a major clinical problem.… read more here.
Keywords: tam; por; breast cancer; resistance ... See more keywords
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2254-4
Abstract: Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls lead to a… read more here.
Keywords: induced gene; tamoxifen; recombinase induced; cre recombinase ... See more keywords
Developmental and reproductive effects of tamoxifen on Daphnia magna
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Monitoring and Assessment"
DOI: 10.1007/s10661-018-7002-y
Abstract: Although medicines are less toxic than other toxicants, increased production and usage of pharmaceuticals have led to many concerns regarding their toxic effects on human and non-target organisms. Additionally, reproductive toxicity after long-term exposure is… read more here.
Keywords: daphnia magna; developmental reproductive; magna; reproductive effects ... See more keywords
Transition of stable patients from traditional anticoagulation clinic services to telephonic management
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DOI: 10.1007/s11096-017-0428-4
Abstract: Background Outpatient warfarin dosing and monitoring with telephonic anticoagulation management (TAM) could be an effective alternative to other more labor intensive management models. Objectives To evaluate the time in therapeutic range (TTR) and number of… read more here.
Keywords: anticoagulation; traditional anticoagulation; management; tam ... See more keywords
Clinical features of 35 Down syndrome patients with transient abnormal myelopoiesis at a single institution
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DOI: 10.1007/s12185-020-03066-7
Abstract: Transient abnormal myelopoiesis (TAM) is a unique clonal myeloproliferation characterized by immature megakaryoblasts that occurs in 5–10% of neonates with Down syndrome (DS). Although TAM regresses spontaneously in most patients, approximately 20% of TAM cases… read more here.
Keywords: lbp tam; abnormal myelopoiesis; blast percentage; tam ... See more keywords
Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM‐mediated autophagy, cell differentiation and death
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.120
Abstract: ABSTRACT Breast cancer (BC) is one of the most common female cancers in the world, with estrogen receptor (ER)‐positive BC the most frequent subtype. Tamoxifen (Tam) is an effective drug that competitively binds to the… read more here.
Keywords: cell differentiation; cholesterol; efficacy; breast cancer ... See more keywords
TAM Receptors Are Not Required for Zika Virus Infection in Mice.
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DOI: 10.1016/j.celrep.2017.03.058
Abstract: Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we… read more here.
Keywords: tam receptors; receptors required; infection; mice ... See more keywords
Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.04.040
Abstract: &NA; The objective of the present study was to investigate the effect of tamoxifen (Tam) loaded solid lipid nanoparticles (SLNs) on MCF7 Tam‐resistant breast cancer cells (MCF7‐TamR). Tam‐SLNs were produced by the hot homogenization method.… read more here.
Keywords: tam slns; resistance; breast cancer; tam ... See more keywords
Hepatoprotective effect of celecoxib against tamoxifen-induced liver injury via inhibiting ASK-1/JNK pathway in female rats.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116573
Abstract: Hepatotoxicity is a common side effect encountered with tamoxifen (TAM) administration. Due to the great value of TAM in breast cancer treatment, hepato-protection is seriously recommended. AIMS The present study investigated the hepato-protective effect of… read more here.
Keywords: ask jnk; effect; effect celecoxib; tam ... See more keywords