Tumor progression is independent of tumor-associated macrophages in cell lineage-based mouse models of glioblastoma.
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DOI: 10.1073/pnas.2222084120
Abstract: Macrophage targeting therapies have had limited clinical success in glioblastoma (GBM). Further understanding the GBM immune microenvironment is critical for refining immunotherapeutic approaches. Here, we use genetically engineered mouse models and orthotopic transplantation-based GBM models… read more here.
Keywords: cell lineage; tam depletion; tumor; gbm ... See more keywords