TAM receptors: A phosphatidylserine receptor family and its implications in viral infections.
Sign Up to like & getrecommendations! Published in 2020 at "International Review of Cell and Molecular Biology"
DOI: 10.1016/bs.ircmb.2020.09.003
Abstract: Phosphatidylserine (PS) is an anionic phospholipid that is usually localized in the inner leaflets of the plasma membrane. However, the enzyme scramblase catalyzes the externalization of PS on the outer leaflet of the plasma membrane… read more here.
Keywords: tam receptors; phosphatidylserine receptor; receptor; family implications ... See more keywords
TAM Receptors Are Not Required for Zika Virus Infection in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.03.058
Abstract: Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we… read more here.
Keywords: tam receptors; receptors required; infection; mice ... See more keywords
Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004863
Abstract: Lung cancer remains a leading cause of cancer death worldwide, with non-small-cell lung cancer (NSCLC) accounting for the majority of cases. Immune checkpoint inhibitors (CPIs), including those targeting programmed cell death protein-1 and its ligand… read more here.
Keywords: tam receptors; resistance nsclc; resistance; cpi resistance ... See more keywords
Abstract 1555: Monoclonal antibodies targeting the TAM family of receptor tyrosine kinases
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-1555
Abstract: The TAM receptors (Tyro3/Axl/MerTK) family of receptor tyrosine kinases (RTKs) are important negative regulators of innate immunity. TAM receptor activation in myeloid cells by its ligands Gas6 or Protein S (PROS) promotes phosphatidylserine-dependent efferocytosis of… read more here.
Keywords: tam receptors; receptor tyrosine; tam; family receptor ... See more keywords
Abstract 4556: Targeting the TAM receptors on prostate cancer tumor-associated macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4556
Abstract: Tumor growth and progression is influenced by the composition of the tumor microenvironment including host stromal cells and immune cells. In prostate cancer, a large proportion of the tumor volume is made up of macrophages,… read more here.
Keywords: associated macrophages; tam receptors; cancer; prostate cancer ... See more keywords
Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer"
DOI: 10.1186/s12943-019-1022-2
Abstract: Tumor-associated macrophages are an abundant cell type in the tumor microenvironment. These macrophages serve as a promising target for treatment of cancer due to their roles in promoting cancer progression and simultaneous immunosuppression. The TAM… read more here.
Keywords: tam receptors; tyro3 axl; cancer; tumor microenvironment ... See more keywords