Association of Adjuvant Tamoxifen and Aromatase Inhibitor Therapy With Contralateral Breast Cancer Risk Among US Women With Breast Cancer in a General Community Setting
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.3340
Abstract: Importance Within 10 years after breast cancer diagnosis, roughly 5% of patients develop contralateral breast cancer (CBC). Randomized trials have found that therapy including tamoxifen citrate and aromatase inhibitors (AIs) reduces CBC risk. But little… read more here.
Keywords: risk; therapy; breast cancer; tamoxifen ... See more keywords
Tamoxifen modulates mitochondrial dynamics through AMPK and MAPK during nutrition deprivation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11853
Abstract: The interaction of cancer cells with their tumor microenvironment determines key events in the progression of the disease, therapeutic efficacy, and the development of drug resistance. Here, we presented evidence that tamoxifen support breast cancer… read more here.
Keywords: nutrition; nutrition deprivation; tamoxifen; mitochondrial fusion ... See more keywords
Effects of tamoxifen on normal breast tissue histological composition: Results from a randomised six‐arm placebo‐controlled trial in healthy women
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34430
Abstract: Tamoxifen prevents recurrence of breast cancer and is suggested for preventive risk‐reducing therapy. Tamoxifen reduces mammographic density, a proxy for therapy response, but little is known about its effects in remodelling normal breast tissue. Our… read more here.
Keywords: normal breast; tamoxifen; tissue; healthy women ... See more keywords
Analysis of tamoxifen and its main metabolites in plasma samples of breast cancer survivor female athletes: Multivariate and chemometric optimization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100899
Abstract: A sensitive method based on liquid chromatography combined with a diode array detector was developed and validated to simultaneously determine tamoxifen, and its active metabolites N-desmethyltamoxifen, 4-hydroxytamoxifen, and endoxifen in human plasma samples. The green… read more here.
Keywords: analysis tamoxifen; tamoxifen main; main metabolites; tamoxifen ... See more keywords
The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2147-y
Abstract: Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact.… read more here.
Keywords: tamoxifen bisphenol; tamoxifen; activity; estrogen like ... See more keywords
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2254-4
Abstract: Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls lead to a… read more here.
Keywords: induced gene; tamoxifen; recombinase induced; cre recombinase ... See more keywords
Pharmacogenomics of breast cancer: highlighting CYP2D6 and tamoxifen
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03206-w
Abstract: Purpose To review recent pharmacogenomics studies on breast cancer patients undergoing tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can help to guide the development of adjuvant therapies for these patients. Methods… read more here.
Keywords: cyp2d6; tamoxifen; tamoxifen metabolism; breast cancer ... See more keywords
Tamoxifen treatment causes early hepatic insulin resistance
Sign Up to like & getrecommendations! Published in 2020 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01468-6
Abstract: Tamoxifen is widely used as an effective adjuvant treatment and prevention of estrogen receptor-positive breast cancer [1]. Tamoxifen decreases food intake, body weight and (at least in the short-term) fat mass in rodents. Despite lowering… read more here.
Keywords: treatment; tamoxifen; tamoxifen treatment; early hepatic ... See more keywords
Impact of estrogen receptor α on the tamoxifen response and prognosis in luminal-A-like and luminal-B-like breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00583-6
Abstract: The luminal-A-like and luminal-B-like breast cancer groups have distinct biological features that lead to differences in the treatment response and clinical outcome. The aim of this study was to examine the value of the distribution… read more here.
Keywords: response; like breast; luminal like; breast cancer ... See more keywords
Novel Use of Tamoxifen to Reduce Recurrent Gastrointestinal Bleeding in Patients with Left Ventricular Assist Devices
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10084-7
Abstract: Gastrointestinal bleeding (GIB) is a frequent complication in patients with continuous-flow left ventricular assist devices (LVAD). We retrospectively evaluated eight patients implanted with a HeartWare LVAD between July 2017 and June 2020 who experienced at… read more here.
Keywords: gastrointestinal bleeding; tamoxifen; assist devices; patient year ... See more keywords
Cytochrome P450 2C9 polymorphism: Effect of amino acid substitutions on protein flexibility in the presence of tamoxifen
Sign Up to like & getrecommendations! Published in 2020 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2019.107166
Abstract: Tamoxifen is a prodrug and cytochrome P450 2C9 (CYP2C9) has a significant role in the formation of a therapeutically more potent metabolite (4-hydroxytamoxifen) than tamoxifen. Since CYP2C9 exhibits genetic polymorphism, it may contribute to different… read more here.
Keywords: amino acid; presence tamoxifen; tamoxifen; biology ... See more keywords