Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202013742
Abstract: Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and… read more here.
Keywords: tamoxifen ameliorates; gb3; disease; tamoxifen ... See more keywords