Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4897-5
Abstract: PurposeGlutathione S-transferase mu 3 (GSTM3) is an enzyme involving in the detoxification of electrophilic compounds by conjugation with glutathione. Higher GSTM3 mRNA levels were reported in patients with ERα-positive breast cancer who received only tamoxifen… read more here.
Keywords: breast; tamoxifen resistance; breast cancer; expression ... See more keywords
MCAM/CD146 promotes tamoxifen resistance in breast cancer cells through induction of epithelial-mesenchymal transition, decreased ERα expression and AKT activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.11.004
Abstract: Tamoxifen resistance presents a prominent clinical challenge in endocrine therapy for hormone sensitive breast cancer. However, the underlying mechanisms that contribute to tamoxifen resistance are not fully understood. In this study, we established a tamoxifen… read more here.
Keywords: resistance breast; resistance; tamoxifen resistance; breast cancer ... See more keywords
Overcoming tamoxifen resistance in oestrogen receptor‐positive breast cancer using the novel thiosemicarbazone anti‐cancer agent, DpC
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DOI: 10.1111/bph.14985
Abstract: Breast cancer is the leading cause of death in women worldwide, with resistance to current therapeutic strategies, including tamoxifen, causing major clinical challenges and leading to more aggressive and metastatic disease. To address this, novel… read more here.
Keywords: tamoxifen resistance; breast cancer; resistance; overcoming tamoxifen ... See more keywords
Downregulation of LINC00894-002 Contributes to Tamoxifen Resistance by Enhancing the TGF-β Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918050139
Abstract: Tamoxifen is a widely used personalized medicine for estrogen receptor (ER)-positive breast cancer, but approximately 30% of patients receiving the treatment relapse due to tamoxifen resistance (TamR). Recently, several reports have linked lncRNAs to cancer… read more here.
Keywords: linc00894 002; group; tamoxifen resistance; signaling pathway ... See more keywords
Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer
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DOI: 10.1158/1078-0432.ccr-17-2776
Abstract: Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms of tamoxifen resistance and provide actionable drug… read more here.
Keywords: resistance; positive breast; tamoxifen resistance; breast cancer ... See more keywords
Abstract 3606: RBP2 promotes tamoxifen resistance by altering ER function and activating IGF1R and EGFR/HER2 signaling in histone methylation-dependent and -independent manners in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3606
Abstract: Retinoblastoma binding protein 2 (RBP2, also known as JARID1A), a member of the JARID1 family of histone H3 lysine K4 demethylases, has been considered to have an oncogenic potential in several types of human cancers… read more here.
Keywords: cancer; rbp2; tamoxifen resistance; breast cancer ... See more keywords
Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling
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DOI: 10.1177/1535370219854678
Abstract: Acquired tamoxifen-resistance is an important cause of death in patients with hormone-dependent breast tumors. Therefore, understanding the molecular mechanisms underlying the development of tamoxifen-resistance is critical for successful endocrine therapy. This study aimed to define… read more here.
Keywords: domain containing; containing oxidoreductase; resistance; tamoxifen resistance ... See more keywords
Association of tamoxifen resistance and lipid reprogramming in breast cancer
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DOI: 10.1186/s12885-018-4757-z
Abstract: BackgroundTamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% will acquire the resistance during the treatment.MethodsIn… read more here.
Keywords: breast; tamoxifen resistance; breast cancer; tamoxifen resistant ... See more keywords
Genome-wide analysis of the FOXA1 transcriptional regulatory network identifies super enhancer associated LncRNAs in tamoxifen resistance
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DOI: 10.3389/fgene.2022.992444
Abstract: Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that… read more here.
Keywords: super enhancer; tamoxifen resistance; enhancer associated; resistance ... See more keywords
Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer
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DOI: 10.3390/cancers13071511
Abstract: Simple Summary This study identifies the molecular mechanisms through which BQ323636.1 can enhance IL-6 and IL-6R expression, which leads to the activation of STAT3 and the development of tamoxifen resistance in ER+ breast cancer. We… read more here.
Keywords: cancer; tamoxifen resistance; breast cancer;
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer
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DOI: 10.3390/cancers14040954
Abstract: Simple Summary Tamoxifen has been used for more than 40 years to treat breast tumors that are dependent on the hormone estrogen for their growth. However, resistance and recurrence of the tumors during the course… read more here.
Keywords: breast; breast cancer; tamoxifen resistance; spred2 ... See more keywords