Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03303
Abstract: The first total synthesis of (-)-TAN-2483B, a fungal metabolite possessing a densely functionalized furo[3,4-b]pyran-5-one framework, is achieved in 14 steps from d-mannose. Generation of the 2,6-trans-pyran is by cyclopropane ring expansion followed by α-selective alkynylation.… read more here.
Keywords: total synthesis; synthesis bioactivity; tan 2483b; fungal metabolite ... See more keywords