Tanshinone IIA regulates CCl4 induced liver fibrosis in C57BL/6J mice via the PI3K/Akt and Nrf2/HO‐1 signaling pathways
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23648
Abstract: Chronic liver diseases caused by various factors may develop into liver fibrosis (LF). Early stage of LF could be reversible. Tanshinone IIA (Tan IIA), an extract from Salvia miltiorrhiza, has been reported to be hepatoprotective.… read more here.
Keywords: tan iia; tanshinone iia; akt nrf2; liver fibrosis ... See more keywords
Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23511
Abstract: It's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the present study, we investigated the preventative effect of Tan IIA on APAP‐induced nephrotoxicity. Mice were orally administrated with Tan IIA (10 or… read more here.
Keywords: nrf2 mrp2; iia; tan iia; mice ... See more keywords
Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01083-3
Abstract: Activator protein-1 (AP-1) plays a decisive role in cell proliferation, apoptosis, and inflammation under hypoxia; thus, AP-1 subunits or dimers could be modulated for a desired phenomenon in a cell using a suitable compound of… read more here.
Keywords: nrf2 transcription; cell survival; tan iia; tanshinone iia ... See more keywords
Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172419
Abstract: Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, in the current study, we investigate whether and how Tanshinone IIa (Tan IIa) from Salvia miltiorrhiza protects bovine retinal… read more here.
Keywords: mgo; tan iia; mitochondrial fission; iia ... See more keywords
RasGRF1 participates in the protective effect of tanshinone IIA on depressive like behaviors of a chronic unpredictable mild stress induced mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144817
Abstract: Tanshinone IIA (Tan IIA) is reported to have neuroprotective effects to suppress cell apoptosis of cortical neurons induced by Aβ25-35 through inhibiting oxidative stress. Nevertheless, few studies have investigated the effects of Tan IIA on… read more here.
Keywords: tan iia; tanshinone iia; like behaviors; stress ... See more keywords
Prospective therapeutic potential of Tanshinone IIA: An updated overview.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105364
Abstract: In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an… read more here.
Keywords: medicine; tan iia; tanshinone iia; therapeutic potential ... See more keywords
Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00535-x
Abstract: Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages, contributing to inflammatory responses. Tanshinone IIA (Tan-IIA) is a major constituent from Salvia miltiorrhiza Bunge, which exhibits anti-inflammatory activity. In this study, we investigated… read more here.
Keywords: inflammatory responses; tan iia; tanshinone iia; nlrp3 inflammasome ... See more keywords
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway
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DOI: 10.1038/s41598-021-98948-z
Abstract: In the present study, we aimed to find the target of Tanshinone IIA (Tan-IIA) in Cholangiocarcinoma by network pharmacology-based prediction and investigate the possible mechanism through experimental verification. In this study, we combined Tan-IIA-specific and… read more here.
Keywords: tan iia; cholangiocarcinoma cells; pharmacology; mtor ... See more keywords
Protective effect of tanshinone IIA against Listeria monocytogenes infection in vitro and in vivo
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DOI: 10.1038/s41598-025-19988-3
Abstract: Listeriolysin O (LLO) is a vital virulence factor for the intracellular replication and pathogenesis of Listeria monocytogenes. The search for an effective LLO activity inhibitor as an alternative approach for the treatment of L. monocytogenes… read more here.
Keywords: tan iia; monocytogenes infection; iia; listeria monocytogenes ... See more keywords
Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201807
Abstract: Abstract Gastric cancer represents a malignant type of cancer worldwide. Tanshinone IIA (Tan IIA), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been reported to possess… read more here.
Keywords: tan iia; gastric cancer; iia; lipid peroxidation ... See more keywords
Tanshinone IIA alleviates LPS-induced acute kidney injury by inhibiting RIP3/Nrf2-mediated oxidative stress.
Sign Up to like & getrecommendations! Published in 2025 at "Renal failure"
DOI: 10.1080/0886022x.2025.2593719
Abstract: Abstract Background Oxidative stress is a critical pathological mechanism in septic acute kidney injury (AKI). Tanshinone IIA (Tan IIA), a bioactive compound derived from Salvia miltiorrhiza, exhibits antioxidative properties. This study aimed to explore the… read more here.
Keywords: tan iia; oxidative stress; iia; rip3 nrf2 ... See more keywords