Phosphine‐Catalyzed 1,6‐Addition and Tandem Addition/Self‐Aldol Condensation Reactions of para‐Quinone Methides with Thiols
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DOI: 10.1002/ejoc.202400130
Abstract: Phosphine‐catalyzed chemodivergent reactions of para‐quinone methides (p‐QMs) affording a wide variety of diarylmethyl thioether derivatives have been reported. In the transformation presented in this work, P(4‐FC6H4)3 catalyzed the direct 1,6‐addition of p‐QMs with thiols, whereas… read more here.
Keywords: para quinone; quinone methides; addition; tandem addition ... See more keywords
Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.
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DOI: 10.1021/acs.orglett.6b03499
Abstract: The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones.… read more here.
Keywords: isoquinolines isoquinolones; addition; tandem addition; addition cyclization ... See more keywords
Sequential Tandem Addition to a Tungsten-Trifluorotoluene Complex: A Versatile Method for the Preparation of Highly Functionalized Trifluoromethylated Cyclohexenes.
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DOI: 10.1021/jacs.7b05118
Abstract: The effects of an electron-withdrawing group on the organic chemistry of an η2-bound benzene ring are explored using the complex TpW(NO)(PMe3)(η2-PhCF3). This trifluorotoluene complex was found to undergo a highly regio- and stereoselective 1,2-addition reaction… read more here.
Keywords: trifluorotoluene; sequential tandem; addition; trifluorotoluene complex ... See more keywords
Electrochemically Driven Tandem Addition–Cyclization: Synthesis of Thiadiazinanes and Thiophosphonates
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DOI: 10.1039/d5gc01831e
Abstract: We herein report a robust electrochemical one-pot two-step strategy for the efficient synthesis of valuable 1,2,5-thiadiazinane and thiophosphonate derivatives. The methodology employs electricity as a clean oxidant and catalytic tetrabutylammonium... read more here.
Keywords: cyclization synthesis; electrochemically driven; addition cyclization; synthesis ... See more keywords