An Asymmetric Synthesis of (+)-Isostrychnine Based on Catalytic Asymmetric Tandem Double Michael Addition.
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DOI: 10.1021/acs.orglett.1c01828
Abstract: Herein, a concise asymmetric synthesis of (+)-isostrychnine is achieved in nine longest-linear steps with a 16% overall yield. The key features of this synthesis include the catalytic asymmetric tandem double Michael addition of a tryptamine-derived… read more here.
Keywords: tandem double; asymmetric tandem; synthesis isostrychnine; double michael ... See more keywords
Tandem Double-Cross-Coupling/Hydrothiolation Reaction of 2-Sulfenyl Benzimidazoles with Boronic Acids.
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DOI: 10.1021/acs.orglett.9b02067
Abstract: A new tandem palladium-catalyzed reaction involving a Suzuki-Miyaura coupling, a desulfenylative coupling, and a hydrothiolation of a triple bond is reported. Notably, the desulfenylative coupling occurs without copper(I) assistance and the hydrothiolation is totally regioselective… read more here.
Keywords: sulfenyl; double cross; tandem double; reaction ... See more keywords
Tandem double hydrophosphination of α,β,γ,δ-unsaturated-1,3-indandiones: diphosphine synthesis, mechanistic investigations and coordination chemistry.
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DOI: 10.1039/c9cc05384k
Abstract: A metal-free tandem double hydrophosphination of extended conjugated indandiones has been established. Mechanistic investigations confirmed the consecutive manner of the nucleophilic addition reaction. Complexation of the generated keto-diphosphine resulted in the formation of an unexpected… read more here.
Keywords: coordination; tandem double; mechanistic investigations; chemistry ... See more keywords