DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.02.057
Abstract: Abstract An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the… read more here.
Keywords: synthesis; promoted tandem; polysubstituted pyrroles; synthesis polysubstituted ... See more keywords
Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition-Intramolecular Aldol Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01745
Abstract: A strategy for constructing a tricyclo[4.3.1.03,7]decane skeleton, which is common to many polycyclic polyprenylated acylphloroglucinols, has been established. The key step was a tandem Michael addition-intramolecular aldol reaction with 3-ethoxy-1-phenyl-2-proyn-1-one, which affords a tricyclo[4.3.1.03,7]decane skeleton… read more here.
Keywords: addition intramolecular; michael addition; aldol reaction; intramolecular aldol ... See more keywords