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Tandem synthesis, cytotoxicity, and in silico study of new 1,3,4‐oxadiazoles as potential thymidylate synthase inhibitors

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0 Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200170

Abstract: A new series of pyrrole‐linked mono‐ and bis(1,3,4‐oxadiazole) hybrids, attached to various arene units, was prepared using a two‐step tandem protocol. Therefore, a benzohydrazide derivative was condensed with the appropriate aldehydes in ethanol at 80°C… read more here.

Keywords: inhibition percentages; thymidylate synthase; tandem synthesis; cytotoxicity ... See more keywords

Base‐promoted tandem synthesis of 6‐H‐phenanthridine and its derivatives

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0 Published in 2025 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202401334

Abstract: Herein, we proposed a simple approach for synthesizing 6‐H‐phenanthridine through, which was a tandem reaction and promoted by base. 2'‐Fluoro‐[1,1'‐biphenyl]‐2‐carbaldehydes and LiN(SiMe3)2 were simply added and combined to obtain different structures of 6‐H‐phenanthridines (25 examples,… read more here.

Keywords: phenanthridine derivatives; tandem synthesis; base; synthesis phenanthridine ... See more keywords

Cobalt(II) Coordination Polymer-Based Catalyst for Tandem Synthesis of Imines and CO2 Fixation for Synthesis of Cyclic Carbonates under Mild Conditions.

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0 Published in 2025 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.5c04422

Abstract: Single crystals of a new cobalt(II)-based coordination polymer (CP), designated as IITG-11 (IITG stands for Indian Institute of Technology), were solvothermally synthesized. The activated form of CP (IITG-11a) possesses coordinatively unsaturated Co(II) metal sites within… read more here.

Keywords: catalyst; coordination polymer; synthesis imines; tandem synthesis ... See more keywords

Reusable TsOH-H2SO4 Mixed Catalysis for Tandem Synthesis of Biodiesel and Oxygenated Fuel Additives, tert-Butyl Glycerol Ethers.

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0 Published in 2021 at "Journal of oleo science"

DOI: 10.5650/jos.ess21001

Abstract: A mixture of p-toluenesulfonic acid and sulfuric acid (TsOH-H2SO4) was used as a catalyst with a good performance in transesterification of palm oil (PO) with methanol and etherification of crude glycerol with isobutylene (tandem synthesis).… read more here.

Keywords: tandem synthesis; tsoh h2so4; glycerol;