Tandem Transformations via Friedel-Crafts Acylation Followed by a Ring-Expansion, Ring-Opening, and Cycloisomerization Sequence.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03881
Abstract: A tandem synthetic route to a diverse array of cyclic compounds has been developed from Friedel-Crafts acylation of alkynes followed by the microwave irradiation of β-chlorovinyl ketone intermediates. The stereoisomeric β-chlorovinyl ketone intermediates smoothly underwent… read more here.
Keywords: crafts acylation; tandem transformations; friedel crafts; ring expansion ... See more keywords
Tandem C–H Transformations by a Single Iridium Catalyst: Direct Access to Indoles and Indolines from o-Alkyl-N-methylanilines
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b05579
Abstract: In the presence of an iridium catalyst bearing DTBM-SEGPHOS as a ligand and tert-butylethylene as a hydrogen scavenger, 2-ethyl-N-methylanilines were converted directly to 3-methylindoles in high yields. The reaction proceeded efficiently in mesitylene at 150… read more here.
Keywords: iridium; transformations single; iridium catalyst; tandem transformations ... See more keywords