Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction.
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DOI: 10.1016/j.tet.2018.04.051
Abstract: The jujubosides are saponin natural products reported to have immunoadjuvant, anticancer, antibacterial, antifungal, and antisweet activities. The triterpene component, jujubogenin contains a unique tricyclic ketal motif comprising the DEF ring system. Herein, we describe our… read more here.
Keywords: diels alder; wolff rearrangement; tandem wolff; rearrangement intramolecular ... See more keywords