Cyclic stretch regulates immune responses via tank‐binding kinase 1 expression in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13526
Abstract: Macrophages distributed in tissues throughout the body contribute to homeostasis. In the inflammatory state, macrophages undergo mechanical stress that regulates the signal transduction of immune responses and various cellular functions. However, the effects of the… read more here.
Keywords: stretch; immune responses; cyclic stretch; tank binding ... See more keywords
TANK-binding kinase 1 (TBK1): an emerging therapeutic target for drug discovery.
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DOI: 10.1016/j.drudis.2021.05.016
Abstract: Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and progression of many diseases, such as inflammation, autoimmune diseases, metabolic diseases, and cancer. Therefore, there is a need to develop TBK1 inhibitors as… read more here.
Keywords: drug discovery; tank binding; binding kinase; kinase tbk1 ... See more keywords
Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.05.051
Abstract: There is currently no specific drug for the treatment of sepsis and antibiotic administration is considered the best option, despite numerous issues. Therefore, the development of drugs to control the pathogen-induced inflammatory responses associated with… read more here.
Keywords: sepsis; tank binding; drug repositioning; inhibitor cyt387 ... See more keywords
Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2
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DOI: 10.1016/j.jgr.2016.02.001
Abstract: Background Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated… read more here.
Keywords: anti inflammatory; tank binding; kinase; interferon ... See more keywords
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
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DOI: 10.1038/s41467-021-22003-8
Abstract: Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here,… read more here.
Keywords: kv3 potassium; binding kinase; tank binding; kv3 ... See more keywords
Targeting TANK-binding kinase 1 (TBK1) in cancer
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DOI: 10.1080/14728222.2020.1826929
Abstract: ABSTRACT Introduction TANK-binding kinase 1 (TBK1) is a Ser/Thr kinase with a central role in coordinating the cellular response to invading pathogens and regulating key inflammatory signaling cascades. While intact TBK1 signaling is required for… read more here.
Keywords: tank binding; kinase tbk1; tbk1 cancer; tbk1 ... See more keywords
Neuropathological characterization of a novel TANK binding kinase (TBK1) gene loss of function mutation associated with amyotrophic lateral sclerosis
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DOI: 10.1111/nan.12578
Abstract: Mutations in TANK binding kinase gene (TBK1) are causative in amyotrophic lateral sclerosis (ALS), however correlations between clinical features and TBK1 mutations have not been fully elucidated. We aimed to identify and compare TBK1 mutations… read more here.
Keywords: tank binding; amyotrophic lateral; gene; binding kinase ... See more keywords
Comparative In Silico Analysis and Functional Characterization of TANK-Binding Kinase 1–Binding Protein 1
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics and Biology Insights"
DOI: 10.1177/11779322231164828
Abstract: Protein modelling plays a vital role in the drug discovery process. TANK-binding kinase 1–binding protein 1 is also called an adapter protein, which is encoded by gene TBK1 present in Homo sapiens. It is found… read more here.
Keywords: binding protein; kinase binding; structure; tank binding ... See more keywords