Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell-derived extracellular vesicles in stirred-tank bioreactors.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28378
Abstract: Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) act as signalling mediators of cellular responses. However, despite representing a promising alternative to cell-based therapies, clinical translation of EVs is currently limited by their lack… read more here.
Keywords: cell; extracellular vesicles; mesenchymal stromal; manufacture ... See more keywords
The transient expression of CHIKV VLP in large stirred tank bioreactors
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00346-x
Abstract: Transient gene expression (TGE) bioprocesses have been difficult to scale up in large stirred tank bioreactors with volumes of more than 1.5 L. Low production levels are often observed, but the causes have not been… read more here.
Keywords: stirred tank; transient expression; tank bioreactors; large stirred ... See more keywords
Performance of fungal microparticle-enhanced cultivations in stirred tank bioreactors depends on species and number of process stages
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107696
Abstract: Abstract Species-dependent mechanisms of morphological development affect filamentous fungi cultivations. In order to influence fungal morphology microparticle-enhanced cultivations (MPEC) were used towards four species exhibiting various mechanisms of morphology formation: a spore agglomerative Aspergillus terreus,… read more here.
Keywords: hyphae agglomerative; microparticle enhanced; tank bioreactors; enhanced cultivations ... See more keywords
Automated multi-scale cascade of parallel stirred-tank bioreactors for fast protein expression studies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2021.03.021
Abstract: Automation, parallelization and autonomous operation of standard lab equipment, usually applied for manual bioprocess development, is considered as the key for reduction of bioprocess development time and costs. An automated bioreactor system with 4 stirred-tank… read more here.
Keywords: protein expression; tank bioreactors; parallel stirred; stirred tank ... See more keywords
Advancing the robust manufacture of t-cell therapies through the application of stirred tank bioreactors
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.365
Abstract: Background & Aim With over 90 active trials in the United States with many more in pre-clinical phases T-Cell immunotherapies represent a large share of the expansion we are observing in the regenerative medicine industry.… read more here.
Keywords: cell therapies; stirred tank; tank bioreactors; cell ... See more keywords
Key Microbes and Metabolic Potentials Contributing to Cyanide Biodegradation in Stirred-Tank Bioreactors Treating Gold Mining Effluent
Sign Up to like & getrecommendations! Published in 2019 at "Mineral Processing and Extractive Metallurgy Review"
DOI: 10.1080/08827508.2019.1575213
Abstract: ABSTRACT Microbial community and metabolic potential changes in a biological wastewater treatment reactor were investigated using phylogenetic and functional profile analysis from 16S rRNA-gene-based pyrosequencing. Stirred-tank bioreactors fed by cyanide-containing synthetic solutions were inoculated with… read more here.
Keywords: key microbes; tank bioreactors; stirred tank; metabolic potentials ... See more keywords
LED Illumination Modules Enable Automated Photoautotrophic Cultivation of Microalgae in Parallel Milliliter-Scale Stirred-Tank Bioreactors
Sign Up to like & getrecommendations! Published in 2023 at "Applied Sciences"
DOI: 10.3390/app13085064
Abstract: Scalable lab-scale photobioreactors are needed for the exploration of new and improved photoautotrophic bioprocesses. Microbioreactor systems in which parallel bioreactors operate automatically are frequently employed to increase the speed of strain selection as well as… read more here.
Keywords: scale; illumination modules; led illumination; stirred tank ... See more keywords