Application of two-dimensional binary fingerprinting methods for the design of selective Tankyrase I inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Diversity"
DOI: 10.1007/s11030-017-9793-0
Abstract: In the present study, five important binary fingerprinting techniques were used to model novel flavones for the selective inhibition of Tankyrase I. From the fingerprints used: the fingerprint atom pairs resulted in a statistically significant… read more here.
Keywords: application two; binary fingerprinting; two dimensional; model ... See more keywords
Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2017.10.017
Abstract: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act… read more here.
Keywords: inhibition tankyrase; tankyrase inhibitors; bone; tankyrase ... See more keywords
MicroRNA‐206 inhibits influenza A virus replication by targeting tankyrase 2
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Microbiology"
DOI: 10.1111/cmi.13281
Abstract: Due to the frequent mutations, influenza A virus (IAV) becomes resistant to anti‐viral drugs targeting influenza viral proteins. There are increasing interests in anti‐viral agents that target host cellular proteins required for virus replication. Tankyrase… read more here.
Keywords: mir 206; tnks2; virus replication; tankyrase ... See more keywords
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.245811
Abstract: ABSTRACT In >95% of cases of amyotrophic lateral sclerosis (ALS) and ∼45% of frontotemporal degeneration (FTD), the RNA/DNA-binding protein TDP-43 is cleared from the nucleus and abnormally accumulates in the cytoplasm of affected brain cells.… read more here.
Keywords: tdp; amyotrophic lateral; tankyrase; tdp protein ... See more keywords