Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis.
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DOI: 10.1016/j.bone.2017.10.017
Abstract: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act… read more here.
Keywords: inhibition tankyrase; tankyrase inhibitors; bone; tankyrase ... See more keywords