Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
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DOI: 10.1073/pnas.2122805119
Abstract: Significance Virus-induced signal adaptor (VISA)/mitochondrial antiviral signaling protein (MAVS) is an essential adaptor protein in innate immune response to RNA viruses; understanding how VISA is regulated is important for the treatment of infectious diseases. In… read more here.
Keywords: tankyrases inhibit; response; rnf146; antiviral response ... See more keywords