Recovery of chicken growth plate by TanshinoneⅡA through wnt/β-catenin pathway in thiram-induced Tibial Dyschondroplasia.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109575
Abstract: Tibial Dyschondroplasia (TD), a metabolic disease of fast growing poultry birds that effects the growth of bone and cartilage, is characterized by anorexia, mental depression and lameness. Wnt/β-catenin pathway can mediate the occurrence of TD,… read more here.
Keywords: tanshinone; catenin pathway; growth; wnt catenin ... See more keywords
GW29-e0781 Tanshinone IIA protects against heart failure post-acute myocardial Infarction via improving AMPK/Beclin1-dependent autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.524
Abstract: Tanshinone IIA is a monomer in traditional Chinese medicine Salvia miltiorrhiza, and has a cardioprotective effect on heart failure after myocardial infarction. The purpose of this study is that tanshinone IA could improve cardiac function… read more here.
Keywords: tanshinone; myocardial infarction; tanshinone iia; heart failure ... See more keywords
A tanshinone I derivative enhances the activities of antibiotics against Staphylococcus aureus in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Research in microbiology"
DOI: 10.1016/j.resmic.2016.08.002
Abstract: Infections caused by Staphylococcus aureus are prevalent. The dramatically reduced discovery of new antibiotics, as well as the persistent emergence of resistant bacteria, represents a major health problem in both hospital and community settings. Using… read more here.
Keywords: tanshinone; tanshinone derivative; staphylococcus aureus; derivative enhances ... See more keywords
Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01967
Abstract: Natural products provide inspiration and have proven to be the most valuable source for drug discovery. Herein, we report a scaffold hybrid strategy of Tanshinone I for the discovery of NLRP3 inflammasome inhibitors. 36 compounds… read more here.
Keywords: potent nlrp3; tanshinone; scaffold hybrid; discovery ... See more keywords
Relaxant Effect of Sodium Tanshinone IIA Sulphonate on Mouse Tracheal Smooth Muscle.
Sign Up to like & getrecommendations! Published in 2017 at "Planta medica"
DOI: 10.1055/s-0042-119950
Abstract: Sodium tanshinone IIA sulphonate, a water-soluble derivative of tanshinone IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive. This paper presents a study on the… read more here.
Keywords: tanshinone; sodium tanshinone; iia sulphonate; tanshinone iia ... See more keywords
Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2020.1865412
Abstract: CONTEXT Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain. OBJECTIVE We investigated the potential beneficial… read more here.
Keywords: tanshinone; mice; tanshinone iia; aom dss ... See more keywords
Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3η
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/3583921
Abstract: Tanshinone IIA is an important component that is isolated from danshen (Salvia miltiorrhiza), which is known to be beneficial for cardiovascular health. In this study, we determined the effects of Tanshinone IIA and its underlying… read more here.
Keywords: tanshinone; tanshinone iia; translocation; anoxia reoxygenation ... See more keywords
The Attenuation of Traumatic Brain Injury via Inhibition of Oxidative Stress and Apoptosis by Tanshinone IIA
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/4170156
Abstract: Traumatic brain injury (TBI) is a major source of mortality and long-term disability worldwide. The mechanisms associated with TBI development are poorly understood, and little progress has been made in the treatment of TBI. Tanshinone… read more here.
Keywords: tanshinone; tanshinone iia; tbi; brain ... See more keywords
Correlations between SmCPS1 promoter polymorphism and tanshinone contents in Salvia miltiorrhiza
Sign Up to like & getrecommendations! Published in 2018 at "Czech Journal of Genetics and Plant Breeding"
DOI: 10.17221/97/2017-cjgpb
Abstract: Copalyl diphosphate synthase 1 (SmCPS1) is the first committed enzyme in tanshinone biosynthesis. The promoter region plays an important role in the transcriptional regulation of genes. Mutations in the promoter region may affect gene expression,… read more here.
Keywords: tanshinone; promoter region; smcps1 promoter; promoter ... See more keywords
Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Current Neurovascular Research"
DOI: 10.2174/1567202614666170306105315
Abstract: Background: Tanshinone IIA is a key active ingredient of danshen, which is derived from the dried root or rhizome of Salviae miltiorrhizae Bge. The tanshinone IIA has protective effects against the focal cerebral ischemic injury.… read more here.
Keywords: tanshinone; reactive oxygen; tanshinone iia; oxygen species ... See more keywords
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201667
Abstract: NQO1 catalyzes the reduction of tanshinones to detoxify lipid peroxyl radicals and inhibit ferroptosis both in vitro and in vivo, providing a molecular mechanism for the therapeutic effects of tanshinones, such as cardiac protection. Ferroptosis… read more here.
Keywords: functions coenzyme; tanshinone; gain function; tanshinone functions ... See more keywords