p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival
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DOI: 10.1007/s00428-018-2324-2
Abstract: The TP63 gene encodes two major protein variants that differ in their N-terminal sequences and have opposing effects. In breast, ΔNp63 is expressed by immature stem/progenitor cells and mature myoepithelial/basal cells and is a characteristic… read more here.
Keywords: breast; p63 isoforms; p63; np63 ... See more keywords
Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5
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DOI: 10.1038/s41598-018-23045-7
Abstract: Abstractp63, a transcriptional factor that belongs to the p53 family, regulates epidermal differentiation, stemness, cell death, tumorigenesis, metastasis, and senescence. However, its molecular mechanism remains elusive. We report here that TAp63 phosphorylated at T46/T281 specifically… read more here.
Keywords: tap63 phosphorylated; phosphorylated t46; t46 t281; late cornified ... See more keywords
TAp63 in Mature POMC Neurons Regulates Glucose and Energy Homeostasis
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DOI: 10.2337/db18-1796-p
Abstract: TAp63 is a transcription factor that has been reported to be important for energy and glucose homeostasis. However, where and how TAp63 functions is unclear. Chow-fed mutant mice with TAp63 deleted from pro-opiomelanocortin (POMC) neurons… read more here.
Keywords: tap63; pomc neurons; energy homeostasis; pomc ... See more keywords
DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
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DOI: 10.3389/fonc.2022.924354
Abstract: The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription domain and consequently has tumor suppressor activities whereas ΔNp63 lacks this domain and acts as an oncogene. The two variants show distinct… read more here.
Keywords: tap63; methylation; dna; squamous cell ... See more keywords