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TAp63 determines the fate of oocytes against DNA damage

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1 Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.ade1846

Abstract: Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target effect. However, their oocyte death pathway has been debated. Here, we clarified the precise mechanism of ovarian depletion induced by cyclophosphamide and doxorubicin. Dormant… read more here.

Keywords: cyclophosphamide doxorubicin; dna damage; tap63 determines; oocyte death ... See more keywords