Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity
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DOI: 10.1038/s41392-018-0020-y
Abstract: TAp73, the homologue of the tumour suppressor p53, has dual roles in tumourigenesis: both as a tumour suppressor and as a promoter of tumour growth. We have recently shown that hypoxia, a condition prevalent in… read more here.
Keywords: stabilisation; ampk activation; tap73; activation ... See more keywords
TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-3177
Abstract: Purpose: Stem-like cancer cells, with characteristic self-renewal abilities, remain highly refractory to various clinical interventions. As such, stemness-inhibiting entities, such as tumor suppressor p53, are therapeutically pursued for their anticancer activities. Interestingly, similar implications for… read more here.
Keywords: cancer stem; like cells; stem like; tap73 ... See more keywords