A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Forensic science international"
DOI: 10.1016/j.forsciint.2021.110825
Abstract: We report a case in which a tapentadol acute intoxication was suspected as the cause of death of a 39-year-old man: approximately two days after death, cardiac and femoral blood, as well as urine, bile,… read more here.
Keywords: tapentadol; intoxication; report; blood ... See more keywords
Comparative study of dezocine, pentazocine and tapentadol on antinociception and physical dependence.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119996
Abstract: AIMS Dezocine and pentazocine, widely prescribed in China for postoperative pain, were initially considered as mixed agonist/antagonist targeting μ-opioid receptors (MORs) and κ-opioid receptors (KORs). However, dezocine has been revealed to alleviate chronic neuropathic pain… read more here.
Keywords: pentazocine; dezocine pentazocine; tapentadol; antinociception ... See more keywords
Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2020.1748876
Abstract: Abstract Objective: This paper presents and discusses recent evidence on the pathophysiological mechanisms of pain. The role of tapentadol – an opioid characterized by an innovative mechanism of action (i.e. µ-opioid receptor [MOR] agonism and… read more here.
Keywords: modulation; tapentadol; sensitization; role ... See more keywords
Appropriate use of tapentadol: focus on the optimal tapering strategy
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2148459
Abstract: Abstract Objective Due to its opioid and non-opioid mechanism of action, tapentadol is considered an atypical opioid with improved gastrointestinal tolerability versus traditional opioids. As for all opioid analgesics it is important to understand how… read more here.
Keywords: tapering strategy; cancer pain; strategy; tapentadol ... See more keywords
Tapentadol exposures and poisonings in Australia
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Toxicology"
DOI: 10.1080/15563650.2022.2074857
Abstract: Abstract Introduction Tapentadol is an atypical opioid with mu-receptor affinity and noradrenaline reuptake inhibition approved for use in Australia in 2011. However, data on tapentadol poisoning are scarce. Objectives To investigate tapentadol poisonings and related… read more here.
Keywords: toxicology; tapentadol poisonings; related deaths; toxicology units ... See more keywords
The Increasing Use and Abuse of Tapentadol and Its Incorporation Into a Validated Quantitative Method.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bky027
Abstract: Tapentadol is a centrally acting synthetic analgesic which is prescribed for the treatment of a range of chronic pain conditions. Its use in treating various pain conditions is increasing and, as with other opioids, it… read more here.
Keywords: mortem; tapentadol; mortem blood; post mortem ... See more keywords
Prescribing trend of tapentadol in a Sydney local health district
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15448
Abstract: Tapentadol, an opioid with mu‐opioid receptor agonism and noradrenaline reuptake inhibition, has been increasingly used in Australia since 2011. However, data on hospital prescribing trends and indications are scarce. This study aimed to investigate hospital… read more here.
Keywords: sydney local; tapentadol; health district; local health ... See more keywords
Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone
Sign Up to like & getrecommendations! Published in 2017 at "BMC Anesthesiology"
DOI: 10.1186/s12871-017-0383-6
Abstract: BackgroundHigh post-operative pain scores after “minor” orthopedic/trauma surgery are in part attributed to inadequate prescription of opioid analgesics. Novel concepts aiming to achieve sufficient analgesia while minimizing opioid-related side effects by avoiding fluctuating plasma levels… read more here.
Keywords: surgery; extended release; tapentadol; trauma ... See more keywords
Tapentadol: an overview of the safety profile
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pain Research"
DOI: 10.2147/jpr.s190154
Abstract: Abstract Long-term opioid therapy may be associated with analgesic efficacy and also predictable adverse events, including cardiovascular and pulmonary events, gastrointestinal disorders, endocrinological harms, psychological problems, impairment of driving ability, and risk of abuse. These… read more here.
Keywords: ability; safety profile; tapentadol; tapentadol overview ... See more keywords
Tapentadol for the Treatment of Moderate-to-Severe Acute Pain in Children Under the Age of Two Years
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pain Research"
DOI: 10.2147/jpr.s269530
Abstract: Background Pharmacokinetics (PK), efficacy, and safety of the opioid analgesic tapentadol in the treatment of moderate-to-severe acute pain have so far not been investigated in pediatric patients read more here.
Keywords: pain; moderate severe; treatment; tapentadol ... See more keywords
Multiple Dose Pharmacokinetics of Tapentadol Oral Solution for the Treatment of Moderate to Severe Acute Pain in Children Aged 2 to
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pain Research"
DOI: 10.2147/jpr.s364902
Abstract: Background This prospective, open-label trial was conducted to fulfil a post-approval commitment made to the competent authorities to extend the indication of the strong opioid analgesic tapentadol hydrochloride oral solution (OS) to the pediatric population.… read more here.
Keywords: trial; pain; model; tapentadol ... See more keywords