Effects of CYP2C19 variants on the metabolism of tapentadol in vitro
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DOI: 10.22038/ijbms.2022.56996.12710
Abstract: Objective(s): This study aims to evaluate the catalytic activities of 31 CYP2C19 alleles and their effects on the metabolism of tapentadol in vitro. Materials and Methods: Insect microsomes expressing the CYP2C19 alleles were incubated with… read more here.
Keywords: metabolism; intrinsic clearance; cyp2c19; tapentadol vitro ... See more keywords