Cytoplasmic Vacuolation and Tapetal Changes Induced by a Novel Analgesic Agent in Beagle Dogs
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DOI: 10.1177/0192623319836678
Abstract: Drug-induced unique cytoplasmic vacuolation was found in the subchronic oral toxicity study of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine (DMIP), a potential therapeutic agent for neuropathic pain, in beagle dogs. In the first study, DMIP was administered at a dose… read more here.
Keywords: vacuolation tapetal; cytoplasmic vacuolation; beagle dogs; vacuolation ... See more keywords