TAR DNA‐binding protein 43 oligomers in physiology and pathology
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DOI: 10.1002/iub.2603
Abstract: TAR DNA‐binding protein 43 (TDP‐43) is an RNA/DNA‐binding protein involved in RNA regulation and diseases. In 2006, TDP‐43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in… read more here.
Keywords: binding protein; dna binding; pathology; physiology ... See more keywords
Antemortem basal forebrain atrophy in pure limbic TAR DNA‐binding protein 43 pathology compared with pure Alzheimer pathology
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DOI: 10.1111/ene.15270
Abstract: Currently, the extent of cholinergic basal forebrain atrophy in relatively pure limbic TAR DNA‐binding protein 43 (TDP‐43) pathology compared with relatively pure Alzheimer disease (AD) is unclear. read more here.
Keywords: pure limbic; limbic tar; pathology; forebrain atrophy ... See more keywords
MicroRNA‐183‐5p regulates TAR DNA‐binding protein 43 neurotoxicity via SQSTM1/p62 in amyotrophic lateral sclerosis
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DOI: 10.1111/jnc.15744
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively attacks motor neurons, and leads to progressive muscle weakness and death. A common pathological feature is the misfolding, aggregation, and cytoplasmic mislocalization of TAR… read more here.
Keywords: mir 183; sqstm1 p62; lateral sclerosis; tar dna ... See more keywords
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant
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DOI: 10.1371/journal.pone.0177181
Abstract: The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, TDP-43… read more here.
Keywords: dna binding; tar dna; binding protein; cleavage ... See more keywords