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   Articles with "target" as a keyword



Objective Assessment of Target Vitiligo Areas by Semiautomatic Analysis of Standardized UV Images.

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recommendations! Published in 2025 at "JAMA dermatology"

DOI: 10.1001/jamadermatol.2025.2740

Abstract: Importance The Target Vitiligo Area Scoring Index (Target-VASI) is the primary tool for evaluating localized vitiligo lesions; however, its uncalibrated estimation in clinical practice is limited by intrarater and interrater variability. While objective methods using… read more here.

Keywords: image; target; target vasi; semiautomatic analysis ... See more keywords

hnRNPU Functions as a Novel Therapeutic Target of c-Myc in the Progression of Hepatocellular Carcinoma.

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recommendations! Published in 2020 at "FEBS letters"

DOI: 10.1002/1873-3468.13943

Abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is… read more here.

Keywords: hepatocellular carcinoma; hnrnpu functions; hcc; target ... See more keywords

A modified glycosylase base editor without predictable DNA off‐target effects

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14970

Abstract: Glycosylase base editor (GBE) can induce C‐to‐G transversion in mammalian cells, showing great promise for the treatment of human genetic disorders. However, the limited efficiency of transversion and the possibility of off‐target effects caused by… read more here.

Keywords: dna target; target effects; glycosylase base; base editor ... See more keywords

Phosphatidylinositol 4-kinase as a target of pathogens-friend or foe?

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recommendations! Published in 2025 at "FEBS letters"

DOI: 10.1002/1873-3468.70216

Abstract: Phosphatidylinositol 4-kinases (PI4Ks) are pivotal enzymes responsible for the generation of phosphatidylinositol 4-phosphate (PI4P), a key precursor involved in various cellular signalling pathways that regulate vesicular trafficking, Golgi maintenance and intracellular communication. Conserved across eukaryotic… read more here.

Keywords: pi4ks; target pathogens; phosphatidylinositol kinase; kinase target ... See more keywords

Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

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recommendations! Published in 2021 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12914

Abstract: Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses either PAX3‐FOXO1 or PAX7‐FOXO1 fusion proteins.… read more here.

Keywords: epigenetic regulator; target; rhabdomyosarcoma; alveolar rhabdomyosarcoma ... See more keywords

SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13343

Abstract: Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed… read more here.

Keywords: nonsense mediated; smg1; decay nmd; mrna decay ... See more keywords

Trajectories toward the 1.5°C Paris target: Modulation by the Interdecadal Pacific Oscillation

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recommendations! Published in 2017 at "Geophysical Research Letters"

DOI: 10.1002/2017gl073480

Abstract: Global temperature is rapidly approaching the 1.5°C Paris target. In the absence of external cooling influences, such as volcanic eruptions, temperature projections are centered on a breaching of the 1.5°C target, relative to 1850–1900, before… read more here.

Keywords: phase; temperature; paris target; interdecadal pacific ... See more keywords

p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

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recommendations! Published in 2018 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12385

Abstract: Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination… read more here.

Keywords: ubiquitin conjugation; p62; endosome rupture; target ... See more keywords

MucR binds multiple target sites in the promoter of its own gene and is a heat‐stable protein: Is MucR a H‐NS‐like protein?

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recommendations! Published in 2018 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12411

Abstract: The protein MucR from Brucella spp. is involved in the expression regulation of genes necessary for host interaction and infection. MucR is a member of the Ros/MucR family, which comprises prokaryotic zinc‐finger proteins and includes… read more here.

Keywords: protein; protein mucr; target; gene ... See more keywords

Technical Note: Using k‐means clustering to determine the number and position of isocenters in MLC‐based multiple target intracranial radiosurgery

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recommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12139

Abstract: Abstract Purpose To present the k‐means clustering algorithm as a tool to address treatment planning considerations characteristic of stereotactic radiosurgery using a single isocenter for multiple targets. Methods For 30 patients treated with stereotactic radiosurgery… read more here.

Keywords: means clustering; position; treatment; target ... See more keywords

Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes

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recommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12189

Abstract: Abstract Purpose Evaluation of dose degradation by anatomic changes for head‐and‐neck cancer (HNC) intensity‐modulated proton therapy (IMPT) relative to intensity‐modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. Methods For… read more here.

Keywords: degradation; impt; dose degradation; target ... See more keywords