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   Articles with "target" as a keyword



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hnRNPU Functions as a Novel Therapeutic Target of c-Myc in the Progression of Hepatocellular Carcinoma.

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recommendations! Published in 2020 at "FEBS letters"

DOI: 10.1002/1873-3468.13943

Abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is… read more here.

Keywords: hepatocellular carcinoma; hnrnpu functions; hcc; target ... See more keywords
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Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

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recommendations! Published in 2021 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12914

Abstract: Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses either PAX3‐FOXO1 or PAX7‐FOXO1 fusion proteins.… read more here.

Keywords: epigenetic regulator; target; rhabdomyosarcoma; alveolar rhabdomyosarcoma ... See more keywords
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SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13343

Abstract: Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed… read more here.

Keywords: nonsense mediated; smg1; decay nmd; mrna decay ... See more keywords
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Trajectories toward the 1.5°C Paris target: Modulation by the Interdecadal Pacific Oscillation

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recommendations! Published in 2017 at "Geophysical Research Letters"

DOI: 10.1002/2017gl073480

Abstract: Global temperature is rapidly approaching the 1.5°C Paris target. In the absence of external cooling influences, such as volcanic eruptions, temperature projections are centered on a breaching of the 1.5°C target, relative to 1850–1900, before… read more here.

Keywords: phase; temperature; paris target; interdecadal pacific ... See more keywords
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p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

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recommendations! Published in 2018 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12385

Abstract: Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination… read more here.

Keywords: ubiquitin conjugation; p62; endosome rupture; target ... See more keywords
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MucR binds multiple target sites in the promoter of its own gene and is a heat‐stable protein: Is MucR a H‐NS‐like protein?

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recommendations! Published in 2018 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12411

Abstract: The protein MucR from Brucella spp. is involved in the expression regulation of genes necessary for host interaction and infection. MucR is a member of the Ros/MucR family, which comprises prokaryotic zinc‐finger proteins and includes… read more here.

Keywords: protein; protein mucr; target; gene ... See more keywords
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Technical Note: Using k‐means clustering to determine the number and position of isocenters in MLC‐based multiple target intracranial radiosurgery

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recommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12139

Abstract: Abstract Purpose To present the k‐means clustering algorithm as a tool to address treatment planning considerations characteristic of stereotactic radiosurgery using a single isocenter for multiple targets. Methods For 30 patients treated with stereotactic radiosurgery… read more here.

Keywords: means clustering; position; treatment; target ... See more keywords
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Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes

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recommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12189

Abstract: Abstract Purpose Evaluation of dose degradation by anatomic changes for head‐and‐neck cancer (HNC) intensity‐modulated proton therapy (IMPT) relative to intensity‐modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. Methods For… read more here.

Keywords: degradation; impt; dose degradation; target ... See more keywords
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Steeper dose gradients resulting from reduced source to target distance—a planning system independent study

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recommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12490

Abstract: Abstract Purpose To quantify the contribution of penumbra in the improvement of healthy tissue sparing at reduced source‐to‐axis distance (SAD) for simple spherical target and different prescription isodoses (PI). Method A TPS‐independent method was used… read more here.

Keywords: distance; reduced sad; target; reduced source ... See more keywords
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The irregular breathing effect on target volume and coverage for lung stereotactic body radiotherapy

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recommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12663

Abstract: Abstract The major challenge in treating a mobile target is obtaining the temporal and spatial information imaging and treatment details. This phantom study quantitatively evaluates the geometric and dosimetric effects of various treatment techniques under… read more here.

Keywords: aip mip; body radiotherapy; target; stereotactic body ... See more keywords
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Technical Note: Comparison of the internal target volume (ITV) contours and dose calculations on 4DCT, average CBCT, and 4DCBCT imaging for lung stereotactic body radiation therapy (SBRT)

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recommendations! Published in 2020 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.13041

Abstract: Abstract Purpose To investigate the differences between internal target volumes (ITVs) contoured on the simulation 4DCT and daily 4DCBCT images for lung cancer patients treated with stereotactic body radiotherapy (SBRT) and determine the dose delivered… read more here.

Keywords: target; stereotactic body; internal target; dose calculations ... See more keywords