LAUSR

Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.

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1 Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c03944

Abstract: The blood-brain barrier (BBB) presents a major hurdle in the development of central nervous system (CNS) active therapeutics, and expression of the P-glycoprotein (P-gp) efflux transporter at the blood-brain interface further impedes BBB penetrance of… read more here.

Keywords: target agnostic; glycoprotein; braf; inhibitor ... See more keywords

Toward Robust Visual Object Tracking With Independent Target-Agnostic Detection and Effective Siamese Cross-Task Interaction

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2 Published in 2023 at "IEEE Transactions on Image Processing"

DOI: 10.1109/tip.2023.3246800

Abstract: Advanced Siamese visual object tracking architectures are jointly trained using pair-wise input images to perform target classification and bounding box regression. They have achieved promising results in recent benchmarks and competitions. However, the existing methods… read more here.

Keywords: cross task; interaction; target agnostic; task ... See more keywords

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients

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2 Published in 2023 at "PLOS Computational Biology"

DOI: 10.1371/journal.pcbi.1011050

Abstract: Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the challenge to rapidly identify… read more here.

Keywords: drug prediction; target agnostic; covid patients; agnostic drug ... See more keywords

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

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0 Published in 2025 at "eLife"

DOI: 10.7554/elife.97865

Abstract: Circulating sexual stages of Plasmodium falciparum (Pf) can be transmitted from humans to mosquitoes, thereby furthering the spread of malaria in the population. It is well established that antibodies can efficiently block parasite transmission. In… read more here.

Keywords: recognition; glutamate rich; identification; target agnostic ... See more keywords