Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03944
Abstract: The blood-brain barrier (BBB) presents a major hurdle in the development of central nervous system (CNS) active therapeutics, and expression of the P-glycoprotein (P-gp) efflux transporter at the blood-brain interface further impedes BBB penetrance of… read more here.
Keywords: target agnostic; glycoprotein; braf; inhibitor ... See more keywords
Toward Robust Visual Object Tracking With Independent Target-Agnostic Detection and Effective Siamese Cross-Task Interaction
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Transactions on Image Processing"
DOI: 10.1109/tip.2023.3246800
Abstract: Advanced Siamese visual object tracking architectures are jointly trained using pair-wise input images to perform target classification and bounding box regression. They have achieved promising results in recent benchmarks and competitions. However, the existing methods… read more here.
Keywords: cross task; interaction; target agnostic; task ... See more keywords
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1011050
Abstract: Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the challenge to rapidly identify… read more here.
Keywords: drug prediction; target agnostic; covid patients; agnostic drug ... See more keywords