Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.02.008
Abstract: In 2011 a novel autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, was described in rheumatoid arthritis (RA) patients. Anti-CarP antibody positivity associates with a more severe disease course, is observed years before disease onset, and may… read more here.
Keywords: carp antibodies; anti carp; rheumatoid arthritis; target anti ... See more keywords
TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5417-7
Abstract: BackgroundPatients with ovarian cancer commonly have a poor prognosis, owing to its invasiveness and distant metastasis. Studies have found TM4SF1 participates in regulating tumor cell invasion and migration. Therefore, it is expected to become a… read more here.
Keywords: invasion; metastasis; expression; ovarian cancer ... See more keywords
Re-visiting EGFR amplification as a target for anti-EGFR therapy: Analysis of cell-free circulating tumor DNA in patients with diverse cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.12028
Abstract: 12028Background: To date, evidence for tissue EGFR amplification (amp)/overexpression as a biomarker for anti-EGFR efficacy has been weak. We investigated the relationship between elevated EGFR cop... read more here.
Keywords: egfr amplification; visiting egfr; anti egfr; amplification target ... See more keywords
YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02930
Abstract: YKL-39 belongs to the evolutionarily conserved family of Glyco_18-containing proteins composed of chitinases and chitinase-like proteins. Chitinase-like proteins (CLPs) are secreted lectins that lack hydrolytic activity due to the amino acid substitutions in their catalytic… read more here.
Keywords: angiogenic therapy; new target; cancer; anti angiogenic ... See more keywords