Variation in Target Attainment of Beta‐Lactam Antibiotic Dosing Between International Pediatric Formularies
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2180
Abstract: As antimicrobial susceptibility of common bacterial pathogens decreases, ensuring optimal dosing may preserve the use of older antibiotics in order to limit the spread of resistance to newer agents. Beta‐lactams represent the most widely prescribed… read more here.
Keywords: variation target; target attainment; attainment beta; beta lactam ... See more keywords
Therapeutic Target Attainment of 3-Hour Extended Infusion of Meropenem in Patients With Septic Burns.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2022.02.007
Abstract: PURPOSE The aim of this prospective cohort study was to evaluate the therapeutic target attainment of 3-hour extended infusion of meropenem in patients with septic burns in the early and late periods of septic shock.… read more here.
Keywords: meropenem; septic burns; patients septic; target ... See more keywords
Population pharmacokinetics of continuous infusion piperacillin/tazobactam in very elderly hospitalized patients and considerations for target attainment against Enterobacterales and Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106408
Abstract: Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very elderly patients. The aims is to conduct a population pharmacokinetic analysis of CI piperacillin/tazobactam and to identify optimal dosages for safe and effective… read more here.
Keywords: permissible doses; continuous infusion; piperacillin; piperacillin tazobactam ... See more keywords
Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piy040
Abstract: Background Metronidazole is traditionally dosed every 6-8 hours even though in adults it has a long half-life, concentration-dependent killing, and 3-hour postantibiotic effect. Based on this logic, some pediatric hospitals adopted once-daily dosing for appendicitis,… read more here.
Keywords: pharmacodynamic properties; properties metronidazole; target attainment; metronidazole pediatric ... See more keywords
1324. Target Attainment of Exebacase, a First-In-Class Antibacterial Lysin, to Determine Optimal Doses for Adult Patients with Staphylococcus aureus (S. aureus) Bloodstream Infections (Bacteremia) Including Endocarditis
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1506
Abstract: Exebacase, a novel, antibacterial direct lytic agent for the treatment of S. aureus bacterimia and endocarditis, studied in Phase 1 and 2 trials, demonstrated potential to improve clinical outcomes when used in addition to conventional… read more here.
Keywords: target attainment; ppk model; consultant; exebacase ... See more keywords
Early Target Attainment With Continuous Infusion Meropenem and Piperacillin/Tazobactam and Utilization of Therapeutic Drug Monitoring in Critically Ill Patients: A Retrospective Cohort Study From 2017 to 2020.
Sign Up to like & getrecommendations! Published in 2023 at "Open forum infectious diseases"
DOI: 10.1093/ofid/ofad143
Abstract: Background We analyzed the attainment of early pharmacological targets of continuous infusion meropenem and piperacillin/tazobactam and the use and effect of a real-time therapeutic drug monitoring (TDM) program on subsequent dosing and target attainment in… read more here.
Keywords: piperacillin tazobactam; target attainment; meropenem;
Long-term clinical impact of low-density lipoprotein cholesterol target attainment according to lesion complexity after percutaneous coronary intervention
Sign Up to like & getrecommendations! Published in 2022 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001138
Abstract: Objective Long-term clinical outcomes of low-density lipoprotein cholesterol (LDL-C) target attainment according to coronary lesion complexity are limited. We investigated the clinical outcomes of LDL-C target attainment after percutaneous coronary intervention (PCI) according to coronary… read more here.
Keywords: target attainment; ldl levels; lesion complexity; ldl ... See more keywords
CMV antiviral stewardship: navigating obstacles to facilitate target attainment
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000001032
Abstract: Purpose of review Despite the availability of potent antivirals, consensus guidelines and decades of research, cytomegalovirus (CMV) continues to be associated with negative outcomes after solid organ transplant. This has been attributed to postprophylaxis CMV… read more here.
Keywords: antiviral stewardship; target attainment; cmi target; cmv ... See more keywords
Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00279-19
Abstract: Fluoroquinolones are group A drugs in tuberculosis guidelines. We aim to compare the culture conversion between new-generation (levofloxacin and moxifloxacin) and old-generation (ciprofloxacin and ofloxacin) fluoroquinolones, develop pharmacokinetic models, and calculate target attainment for levofloxacin… read more here.
Keywords: target attainment; culture conversion; generation; culture ... See more keywords
Ethionamide Population Pharmacokinetic Model and Target Attainment in Multidrug-Resistant Tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00713-20
Abstract: Ethionamide (ETA), an isonicotinic acid derivative, is part of the multidrug-resistant tuberculosis (MDR-TB) regimen. The current guidelines have deprioritized ETA because it is potentially less effective than other agents. Our aim was to develop a… read more here.
Keywords: multidrug resistant; resistant tuberculosis; population; target attainment ... See more keywords
Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Determine Optimal Dosing of Ceftazidime-Avibactam for the Treatment of Acute Pulmonary Exacerbations in Patients with Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00988-17
Abstract: ABSTRACT Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity… read more here.
Keywords: caz; treatment; target; target attainment ... See more keywords