An in silico Approach for Integrating Phenotypic and Target‐based Approaches in Drug Discovery
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Informatics"
DOI: 10.1002/minf.201900096
Abstract: Phenotypic and target‐based approaches are useful methods in drug discovery. The phenotypic approach is an experimental approach for evaluating the phenotypic response. The target‐based approach is a rational approach for screening drug candidates targeting a… read more here.
Keywords: target based; target; drug; approach ... See more keywords
Dam construction material selection by implementing the integrated SWARA–CODAS approach with target-based attributes
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Civil and Mechanical Engineering"
DOI: 10.1016/j.acme.2019.06.010
Abstract: Abstract The selection of the optimal material in engineering design procedures of any construction project due to the complexity of future circumstances could be considered as a complex problem. Similar complex selection problems can be… read more here.
Keywords: construction; target; material selection; target based ... See more keywords
Knowledge production for target-based biodiversity governance
Sign Up to like & getrecommendations! Published in 2021 at "Biological Conservation"
DOI: 10.1016/j.biocon.2021.108980
Abstract: Abstract Target-based governance holds the promise of accountability by measuring progress towards objectives set within global environmental agreements. This approach has been widely adopted at multiple scales of governance in conservation and sustainability sectors including… read more here.
Keywords: governance; protected areas; biodiversity; target ... See more keywords
Target based chemotherapeutic advancement of ruthenium complexes
Sign Up to like & getrecommendations! Published in 2021 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2021.214169
Abstract: Abstract Over the last few years, great emphasis has been given to develop ruthenium complexes to act as target specified chemotherapeutic agents. Indeed, there are few reviews available already, which summarized the literature based on… read more here.
Keywords: ruthenium; ruthenium complexes; chemotherapeutic advancement; target based ... See more keywords
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.030
Abstract: Summary Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. Here, we used surface plasmon resonance to design a method to… read more here.
Keywords: target based; phosphatase; based discovery; target ... See more keywords
Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113781
Abstract: Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This scaffold produced numerous biological activities in which anticancer is important one. Previous studies showed its importance in interactions with various receptors such as… read more here.
Keywords: target based; anticancer agents; pyrazolopyrimidines anticancer; kinase ... See more keywords
Target-based coherent beam combining of an optical phased array fed by a broadband laser source
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Modern Optics"
DOI: 10.1080/09500340.2017.1343403
Abstract: Abstract The target-based phasing of an optical phased array (OPA) fed by a broadband master oscillator laser source is investigated. The specific scenario examined here considers an OPA phasing through atmospheric turbulence on a rough… read more here.
Keywords: target based; fed broadband; laser source; phased array ... See more keywords
Target-based drug discovery through inversion of quantitative structure-drug-property relationships and molecular simulation: CA IX-sulphonamide complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1511551
Abstract: Abstract In this work, a target-based drug screening method is proposed exploiting the synergy effect of ligand-based and structure-based computer-assisted drug design. The new method provides great flexibility in drug design and drug candidates with… read more here.
Keywords: target based; property relationships; quantitative structure; drug ... See more keywords
DIANA-miRPath v4.0: expanding target-based miRNA functional analysis in cell-type and tissue contexts.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad431
Abstract: DIANA-miRPath is an online miRNA analysis platform harnessing predicted or experimentally supported miRNA interactions towards the exploration of combined miRNA effects. In its latest version (v4.0, http://www.microrna.gr/miRPathv4), DIANA-miRPath breaks new ground by introducing the capacity… read more here.
Keywords: cell; diana mirpath; based mirna; analysis ... See more keywords
Medication‐based versus target‐based lipid management
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12789
Abstract: Many clinicians feel strongly about the value of bringing patients’ low-density lipoprotein cholesterol (LDLC) to the risk-appropriate safe zone, be it read more here.
Keywords: target based; based versus; versus target; medication ... See more keywords
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-3645
Abstract: Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We… read more here.
Keywords: target based; inhibitor; eif4a1; target ... See more keywords