Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.
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DOI: 10.1021/acs.jmedchem.8b00862
Abstract: ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of its class. In our recent disclosure of the first chemical probe against this bromodomain, GSK8814 (6), we described the… read more here.
Keywords: aiming miss; moving target; target bromo; bet ... See more keywords