Bioinspired Pollen-Like Hierarchical Surface for Efficient Recognition of Target Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201700003
Abstract: The efficient recognition and isolation of rare cancer cells holds great promise for cancer diagnosis and prognosis. In nature, pollens exploit spiky structures to realize recognition and adhesion to stigma. Herein, a bioinspired pollen-like hierarchical… read more here.
Keywords: pollen like; surface; recognition; target cancer ... See more keywords
Advances in IKBKE as a potential target for cancer therapy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2678
Abstract: IKBKE (inhibitor of nuclear factor kappa‐B kinase subunit epsilon), a member of the nonclassical IKK family, plays an important role in the regulation of inflammatory reactions, activation and proliferation of immune cells, and metabolic diseases.… read more here.
Keywords: potential target; ikbke potential; advances ikbke; target ... See more keywords
Oncolytic immunotherapy: unlocking the potential of viruses to help target cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2025-8
Abstract: Oncolytic immunotherapy is a research area of cancer immunotherapy investigating the use of modified viruses to target cancer cells. A variety of different viral backbones (e.g., adenovirus, reovirus) with a diverse range of genetic modifications… read more here.
Keywords: unlocking potential; immunotherapy; oncolytic immunotherapy; target cancer ... See more keywords
Squalene epoxidase as a promising metabolic target in cancer treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.034
Abstract: Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its… read more here.
Keywords: squalene epoxidase; target; target cancer; cancer treatment ... See more keywords
HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.081
Abstract: Deacetylation of histones by histone deacetylase 3 (HDAC3) is involved in apoptosis, cellular progression and DNA damage. Due to the overexpression of HDAC3 in a variety of cancers, it is implicated to be a crucial… read more here.
Keywords: hdac3 inhibitors; selective hdac3; target cancer; qsar qaar ... See more keywords
Cellular Reprogramming as a Therapeutic Target in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.05.001
Abstract: Cancer heterogeneity has long been recognized as an important clinical determinant of patient outcomes and, thus, many new cancer treatments have been designed to target these different cells. Despite the short-term achievements of current therapies,… read more here.
Keywords: target cancer; biology; reprogramming therapeutic; cancer ... See more keywords
FBXO45 is a potential therapeutic target for cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-0291-2
Abstract: FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe… read more here.
Keywords: fbxo45 potential; target cancer; therapeutic target; potential therapeutic ... See more keywords
CD24 signalling through macrophage Siglec-10 is a new target for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1456-0
Abstract: Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression… read more here.
Keywords: target cancer; cancer immunotherapy; macrophage; cd24 ... See more keywords
MUC16 as a novel target for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1498845
Abstract: ABSTRACT Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe the role of MUC16 under normal physiological conditions… read more here.
Keywords: muc16 novel; muc16; target cancer; novel target ... See more keywords
Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac024
Abstract: In mammalian cells, there are three isoforms of malic enzymes (MEs): a cytosolic nicotinamide adenine dinucleotide phosphate + (NADP + )-dependent isoform (ME1), a mitochondrial NAD(P) + -dependent isoform (ME2), and a mitochondrial NADP +… read more here.
Keywords: therapeutic target; malic enzyme; dependent isoform; enzyme therapeutic ... See more keywords
SATB2 is a novel biomarker and therapeutic target for cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15755
Abstract: Several studies have confirmed the involvement of cancer stem cells (CSC) in tumour progression, metastasis, drug resistance and cancer relapse. SATB2 (special AT‐rich binding protein‐2) acts as a transcriptional co‐factor and modulates chromatin architecture to… read more here.
Keywords: target cancer; expression; therapeutic target; cancer ... See more keywords