The osteoclast, a target cell for microorganisms.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.06.023
Abstract: Bone is a highly adaptive tissue with regenerative properties that is subject to numerous diseases. Infection is one of the causes of altered bone homeostasis. Bone infection happens subsequently to bone surgery or to systemic… read more here.
Keywords: cell microorganisms; target cell; bone; osteoclast target ... See more keywords
Natural products that target the cell envelope.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2021.02.001
Abstract: The inexorable spread of resistance to clinically used drugs demands that we maintain a full pipeline of antibiotic candidates. As organisms have struggled to survive and compete over evolutionary history, they have developed the capacity… read more here.
Keywords: cell envelope; natural products; target cell; products target ... See more keywords
Grainyhead‐like‐2 confers NK‐sensitivity through interactions with epigenetic modifiers
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.11.006
Abstract: HighlightsGRHL2 is a master programmer of the epithelial phenotype that sensitized cells to NK killing at the level of NK‐target cell synaptogenesis.Sensitization was mediated by the up‐regulation of ICAM‐1.GRHL2‐KMT2C/D interactions and p300 inhibition were important… read more here.
Keywords: epithelial phenotype; grainyhead like; expression; target cell ... See more keywords
Kill, but don't be killed
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.367.6473.37-e
Abstract: Cell Biology Cytotoxic T lymphocytes (CTLs) recognize and destroy infected or malignant cells. CTLs secrete the pore-forming protein perforin into the immune synapse, where perforin disrupts the target cell plasma membrane and initiates cell death… read more here.
Keywords: kill killed; target cell; perforin; biology ... See more keywords
Evolution of Host Target Cell Specificity During HIV-1 Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Current HIV research"
DOI: 10.2174/1570162x16666171222105721
Abstract: BACKGROUND Many details of HIV-1 molecular virology have been translated into lifesaving antiviral drugs. Yet, we have an incomplete understanding of the cells in which HIV-1 replicates in untreated individuals and persists in during antiretroviral… read more here.
Keywords: hiv; infection; target cell; target ... See more keywords